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Merck
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SAB3500544

Anti-NOD3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CLR16.2, Anti-NLRC3, Anti-Nucleotide-binding oligomerization domain containing 3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

technique(s)

immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

EAW85351

UniProt accession no.

Q7RTR2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NLRC3(197358)

General description

NLR family CARD domain containing 3 (NLRC3), also referred to as nucleotide-binding oligomerization domain containing 3 (NOD3), is encoded by the gene mapped to human chromosome 16p13.3. The encoded protein belongs to the NLR protein family and is abundantly expressed in purified T cells, B cells and natural killer (NK) cells, but also in thymus, uterus and kidney.

Immunogen

NOD3 antibody was raised against an 18 amino acid peptide near the center of human NOD3.

Biochem/physiol Actions

NLR family CARD domain containing 3 (NLRC3) negatively regulates nuclear factor-κB (NF-κB) activity and innate immune signaling induced by the DNA sensor STING (stimulator of interferon gene). NLRC3 inhibits mammalian target of rapamycin (mTOR) pathways involved in providing protection against colorectal cancer. Thus, downregulated expression of the gene has been observed in colorectal cancer and Wegener′s granulomatosis patients.

Features and Benefits

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Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500544.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
59491003

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Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components
Liu R, et al.
Oncotarget, 6(32), 33456-33456 (2015)
NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING
Zhang L, et al.
Immunity, 40(3), 329-341 (2014)
NLRC3 is an inhibitory sensor of PI3K?mTOR pathways in cancer
Karki R, et al.
Nature, 540(7634), 583-583 (2016)
NLR proteins: integral members of innate immunity and mediators of inflammatory diseases
Wilmanski, et al.
Journal of Leukocyte Biology, 83(1), 13-30 (2008)

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