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SAB4100599

Anti-KRAS Antibody

Name: Anti-KRAS Antibody
Brand: SIGMA

mouse monoclonal, KRAS-A582

Synonym(s):

Anti-C-K-RAS, Anti-K-RAS2A, Anti-K-RAS2B, Anti-K-RAS4A, Anti-K-RAS4B

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Conjugate:

unconjugated

Clone:

KRAS-A582, monoclonal

Application:

Citations:

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Product Name

Anti-KRAS antibody, Mouse monoclonal, clone KRAS-A582, purified from hybridoma cell culture

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

KRAS-A582, monoclonal

form

aqueous solution

mol wt

antigen predicted mol wt 27.9 kDa

species reactivity

human

technique(s)

western blot: suitable using 5-10ug/ml using HEK-293 cells expressing KRAS

isotype

IgG1

UniProt accession no.

P01116

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KRAS(3845)

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General description

The kirsten rat sarcoma-2 virus oncogene (KRAS) gene is mapped to human chromosome 12p12.1 and belongs to the family of Ras genes. The protein encoded is a small guanosine nucleotide-bound GTPases belonging.

Immunogen

KRAS purified recombinant protein

Biochem/physiol Actions

Mutation in the KRAS gene causes non small-cell lung cancer and promotes tumor initiation, progression and metastasis. Altered KRAS gene also offers resistance to chemotherapy. It is involved in the signal transduction between epidermal growth factor receptor (EGFR) to the nucleus.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

Regulatory Information

低风险生物材料

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Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression

Jin H, et al.

Journal of Experimental & Clinical Cancer Research, 38(1), 165-165 (2019)

RAS-expanded mutations and HER2 expression in metastatic colorectal cancer: a new step of precision medicine

Valentini AM, et al.

Applied Immunohistochemistry & Molecular Morphology, 26(8), 539-539 (2018)

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

Tidyman WE and Rauen KA

Current Opinion in Genetics & Development, 19(3), 230-236 (2009)

Global Trade Item Number

SKU	GTIN
SAB4100599-200UL	04061837786037

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