Anti-TRIP6 antibody, Mouse monoclonal

Monoclonal Anti-TRIP6 (mouse IgG1 isotype) is derived from the hybridoma TRP(N)-12 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Thyroid hormone receptor interactor 6 (TRIP6) is a member of the zyxin family. The TRIP6 gene encodes a protein with three Lin11, Isl-1, Mec-3 (LIM) zinc-binding domains at its carboxy- terminus, a proline-rich region and nuclear export signals at its aminoterminus. TRIP6 transcripts are strongly detected in highly vascularized tissues such as lungs, placenta, heart, and kidney. This protein localizes to focal adhesion sites and along actin stress fibers. The TRIP6 gene is mapped on the human chromosome at 7q22.1.

Anti-TRIP6 antibody, Mouse monoclonal may be used in immunoblotting.

Monoclonal Anti-TRIP6 recognizes human and bovine TRIP6.

Thyroid hormone receptor interactor 6 (TRIP6) is recruited to the plasma membrane in a lysophosphatidic acid (LPA)-dependent manner and it also regulates LPA-induced cell migration. This protein is postulated to serve as a docking site for the assembly of multimeric protein complexes involved in regulating cytoskeleton assembly and cell motility.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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