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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB CL
Citations:
6
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~59 kDa
species reactivity
human
enhanced validation
independent
Learn more about Antibody Enhanced Validation
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 1.2-2.5 μg/mL using paraformaldehyde fixed HEK-293T cells, western blot (chemiluminescent): 0.5-1 μg/mL using lysates of HEK-293T cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PSPC1(55269)
General description
Paraspeckle protein 1 (PSP1/ PSPC1) has two isoforms, α and β. PSPC1 belongs to the Drosophila melanogaster behavior, human splicing (DBHS) protein family.
Application
Anti-PSPC1 (N-terminal) antibody produced in rabbit may be used in several immunochemical techniques including immunoblotting (~59 kDa) and immunofluorescence. It has also been used in RNA immunoprecipitation (RIP) experiment.
Biochem/physiol Actions
Paraspeckle protein 1(PSP1/ PSPC1) is implicated in the regulation of nuclear receptors such as the progesterone receptor and the thyroid receptor, and in a wide range of processes such as transcription, splicing, and RNA metabolism. It acts as a marker for paraspeckles, which are ribonucleoprotein bodies found in the interchromatin space of mammalian cell nuclei that are often located adjacent to splicing speckles.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Related Content
Instructions
The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold
Knott GJ, et al.
Nucleic Acids Research, 44(9), 3989-4004 (2016)
Circadian RNA expression elicited by 3?-UTR IRAlu-paraspeckle associated elements
Torres M, et al.
eLife, 5(9), e14837-e14837 (2016)
P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner
Fox AH, et al.
Molecular Biology of the Cell, 16(11), 5304-5315 (2005)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4200068-25UL | 04061838034298 |
| SAB4200068-200UL | 04061838034281 |