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SAB4200078

Anti-Coronin-1A (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

Synonym(s):

Anti-CLABP, Anti-CLIPINA (coronin-like protein A), Anti-CORO1A, Anti-HCORO1, Anti-TACO (tryptophane aspartate-containing coat protein), Anti-p57

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
mouse, human, rat
Citations:
11
Technique(s):
western blot: 1.5-3.0 μg/mL using Jurkat cell lysates, or lysates of mouse brain (S1 fraction) or rat spleen (S1 fraction)
Uniprot accession no.:
P31146

Key Documents

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Product Name

Anti-Coronin-1A (N-terminal) antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~57 kDa

species reactivity

mouse, human, rat

concentration

~1.5 mg/mL

technique(s)

western blot: 1.5-3.0 μg/mL using Jurkat cell lysates, or lysates of mouse brain (S1 fraction) or rat spleen (S1 fraction)

UniProt accession no.

P31146

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... CORO1A(11151)
mouse ... Coro1a(12721)
rat ... Coro1a(155151)

Related Categories

Application

Anti-Coronin-1A (N-terminal) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Coronin 1A (Coronin-1A) plays a vital role in F-actin stabilization in vitro. It is also involved in phagocytosis by neutrophils and macrophages and in T-cell receptor (TCR)-mediated activation of T lymphocytes. Additionally, it is also implicated in the regulation of activate actin-related protein-2/3 (Arp2/3)-dependent processes. Mutation in the gene has been observed in T cell-deficient, B cell- and natural killer (NK) cell-sufficient (T?B+NK+) severe combined immunodeficiency (SCID) patients.
Coronin-1A also plays a vital role in regulation of leukocyte specific signaling. In T-lymphocytes, coronin-1A facilitates the association of cytoskeleton dynamics to TCRαβ induced cell signaling, chemokine-mediated cell migration and homeostasis. Loss of coronin-1A gene expression in murine T cells leads to reduced ability to respond to chemotactic gradient and decrease in peripheral T cells due to apoptosis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Coronin 1A (Coronin-1A) is encoded by the gene mapped to human chromosome 16p11.2. The encoded 57kDa protein, belongs to the coronin family and is mainly expressed in hematopoietic cells. Coronin family of proteins are characterized with a highly conserved N-terminal extension (NE), five canonical WD40 repeats, a C-terminal conserved extension (CE), followed by a unique region (U), and ends with a C-terminal coiled-coil (CC) domain.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
068M4839V
010M4789

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The actin regulator coronin-1A is mutated in a thymic egress deficient mouse strain and in a T?B+NK+ SCID patient
Shiow L R
Nature Immunology, 9, 1307?1315-1307?1315 (2008)
Coronin-1A links cytoskeleton dynamics to TCR alpha beta-induced cell signaling.
Mugnier B
PLoS ONE, 3 (2008)
Christina S Yee et al.
The Journal of allergy and clinical immunology, 137(3), 879-888 (2015-10-20)
Coronin-1A (CORO1A) is a regulator of actin dynamics important for T-cell homeostasis. CORO1A deficiency causes T(-)B(+) natural killer-positive severe combined immunodeficiency or T-cell lymphopenia with severe viral infections. However, because all known human mutations in CORO1A abrogate protein expression, the
Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association.
Yee CS
The Journal of Allergy and Clinical Immunology, 137, 879-888 (2016)
Coronin-1 is a neurotrophin endosomal effector required for developmental competition for survival
Suo D
Nature Neuroscience, 17, 36-45 (2014)
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