SAB4200481
Anti-SATB1 antibody, Mouse monoclonal
clone SAT-5, purified from hybridoma cell culture
Synonym(s):
Anti-SATB homeobox 1, Anti-Special AT-rich sequence-binding protein 1, Monoclonal Anti-SATB1 antibody produced in mouse
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SAT-5, monoclonal
Application:
flow cytometry
immunocytochemistry
western blot
immunocytochemistry
western blot
Species reactivity:
human, mouse, monkey, rat
Citations:
9
Technique(s):
flow cytometry: 5-10 μg using THP-1 cells
immunocytochemistry: suitable
western blot: 2.0-4.0 μg/mL using Jurkat total cell extracts
immunocytochemistry: suitable
western blot: 2.0-4.0 μg/mL using Jurkat total cell extracts
Uniprot accession no.:
Product Name
Anti-SATB1 antibody, Mouse monoclonal, clone SAT-5, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
SAT-5, monoclonal
form
buffered aqueous solution
mol wt
antigen ~100 kDa
species reactivity
human, mouse, monkey, rat
concentration
~1.0 mg/mL
technique(s)
flow cytometry: 5-10 μg using THP-1 cells
immunocytochemistry: suitable
western blot: 2.0-4.0 μg/mL using Jurkat total cell extracts
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SATB1(6304)
Related Categories
Application
Monoclonal Anti-SATB1 antibody produced in mouse has been used in:
- immunoblotting
- immunocytochemistry
- flow cytometry
Biochem/physiol Actions
Special AT-rich sequence-binding protein 1 (SATB1) is a tumor promotor gene that plays an important role in regulating gene expression. The SATB1 known to be involved in organizing higher-order chromatin structure including the subnuclear organization of individual genes within multigene clusters in a tissue specific manner, locally and at a distance. It controls the global chromatin architecture via promyelocytic leukemia protein (PML). SATB1 also regulates the periodic anchoring of matrix attachment regions (MARs) in DNA to the nuclear matrix. This organizes chromatin into distinct loops. Furthermore, SATB1 recruits co-repressor complexes to its binding sites. SATB1 is abnormally expressed in human metastatic breast cancer and also promotes breast cancer tumor growth and metastasis. It is involved in the tumorigenesis of colorectal, coetaneous malignant melanoma and lung cancers. SATB1 also serves as a possible prognostic marker.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-SATB1 (mouse IgG2a isotype) is derived from the hybridoma SAT-5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the N-terminus of human special AT-rich sequence-binding protein 1 (SATB1), conjugated to keyhole limpet hemocyanin (KLH). SATB1 encodes as nuclear matrix protein that interacts with scaffold-associating DNA. SATB1 gene is mapped to human chromosome 3p24.3.
Immunogen
a synthetic peptide corresponding to a sequence at the N-terminus of human SATB1, conjugated to KLH.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer
Selinger CJ, et al.
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 6(7), 1179-1189 (2011)
SATB1 downregulation induced by oxidative stress participates in trophoblast invasion by regulating $\beta$-catenin
Ra H, et al.
Biology of Reproduction, 98(6), 810-820 (2018)
Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1
Purbey PK, et al.
Molecular and Cellular Biology, 29(5), 1321-1337 (2009)
The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1
Galande S, et al.
Current Opinion in Genetics & Development, 17(5), 408-414 (2007)
Correlation of SATB1 overexpression with the progression of human rectal cancer
Meng WJ, et al.
International Journal of Colorectal Disease, 27(2), 143-150 (2012)
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