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Merck
CN

SAB4200539

Anti-Myocardin antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-MYCD, Anti-MYOCD

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-Myocardin antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~107 kDa

species reactivity

rat, human, mouse

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

immunohistochemistry: 5-10 μg/mL using human and chicken heart.
indirect immunofluorescence: 2-4 μg/mL using A10 cells.
western blot: 1.5-3.0 μg/mL using extracts of Hct116 cells

UniProt accession no.

Q8IZQ8

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... MYOCD(93649)
mouse ... Myocd(214384)
rat ... Myocd(246297)

Related Categories

Biochem/physiol Actions

Myocardin (MYOCD) acts as an important smooth and cardiac muscle-specific transcriptional coactivator of serum response factor (SRF). It also plays an essential role in smooth muscle cell (SMC) differentiation. The encoded protein regulates bone morphogenetic protein 10 (BMP10) expression and is required for cardiac development, as well as cardiomyocyte survival and maintenance of heart function. MYOCD expression is associated with the development of atherosclerosis, Alzheimer′s disease and malignant transformation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Anti-Myocardin specifically recognizes human, rat and chicken myocardin (MYOCD). Myocardin is encoded by the gene mapped to human chromosome 17p11.2. It contains a conserved SAP (SAF-A/B, Acinus, and PIAS) domain, involved in the regulation of nuclear organization, chromosomal dynamics and apoptosis. The encoded protein is expressed in a precise developmentally regulated, lineage-restricted pattern in the embryo and during postnatal development.

Immunogen

a synthetic peptide corresponding to an internal sequence of human myocardin, conjugated to KLH. The corresponding sequence is identical in human myocardin isoform 2 and in rat and mouse myocardin.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000363246
0000363246
0000348384
0000280972
0000280972

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Myocardin in Tumor Suppression and
Myofibroblast Differentiation
Shats I, et al.
Cell Cycle, 6, 1141-1146 (2007)
Myocardin regulates BMP10 expression and is required for heart development
Huang J, et al.
The Journal of Clinical Investigation, 122, 3678-3691 (2012)
Sofie De Moudt et al.
Physiological reports, 10(18), e15410-e15410 (2022-09-20)
In vivo angiotensin II (AngII)-treatment is a widely used experimental model to induce cardiovascular disease and results in a high likelihood of abdominal aorta aneurysm (AAA) formation. This involves progressive and irreversible focal dilation of the abdominal aorta and induces
Loss of heterozygosity: what is it good for?
Ryland GL, et al.
BMC Medical Genomics (2015)
Sofie De Moudt et al.
Communications biology, 5(1), 605-605 (2022-06-18)
Aortic stiffness is a hallmark of cardiovascular disease, but its pathophysiology remains incompletely understood. This study presents an in-dept characterization of aortic aging in male C57Bl/6 mice (2-24 months). Cardiovascular measurements include echocardiography, blood pressure measurement, and ex vivo organ
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