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Merck
CN

SAB4200565

Monoclonal Anti-ZFP36/TTP antibody produced in mouse

clone TTP6, tissue culture supernatant

Synonym(s):

Anti-G0/G1 switch regulatory protein 24, Anti-G0S24, Anti-Growth factor-inducible nuclear protein NUP475, Anti-NUP475, Anti-RNF162A, Anti-TIS11, Anti-TIS11A, Anti-Zinc finger protein 36 homolog, Anti-tristetraprolin, Anti-zinc finger protein 36, C3H type, homolog (mouse), Anti-zinc finger protein, C3H type, 36 homolog (mouse)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

TTP6, monoclonal

form

buffered aqueous solution

mol wt

antigen ~45 kDa

species reactivity

mouse, bovine, rat, dog, human, monkey

technique(s)

western blot: 1:4,000-1:8,000 using extracts of HepG2 cells.

UniProt accession no.

P26651

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ZFP36(7538)

General description

Monoclonal Anti-ZFP36/TTP (mouse IgM isotype) is derived from the hybridoma TTP6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide corresponding to an internal sequence of human ZFP36/TTP, conjugated keyhole limpet hemocyanin (KLH). ZFP36 (also known as tristetraprolin or TTP) is a RNA-binding protein. It belongs to the RNA-binding zinc-finger protein family. TTP consists of a cysteine-cysteine-cysteine-histidine (CCCH) zinc finger motif and uridine-rich elements (AREs) in the 3′ untranslated region (3′ UTR) of target mRNA. This gene is located on human chromosome 19q13.1.

Immunogen

a peptide corresponding to an internal sequence of human ZFP36/TTP conjugated KLH.

Application

Monoclonal Anti-ZFP36/TTP antibody has been used in immunoblotting.

Biochem/physiol Actions

ZFP36 (also known as tristetraprolin or TTP) participates in controlling the expression of AU-rich element (ARE) -containing mRNAs. It participates in accelerating mRNA decay. ZFP36 was found to limit the expression of a number of critical genes frequently overexpressed in inflammation and cancer. It also plays a major role in differentiation, reprogramming, metabolism, proliferation, pluripotency, tumorigenesis and immunity.

Physical form

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
117M4841V
013M4842V
013M4842

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Tristetraprolin: A novel target of diallyl disulfide that inhibits the progression of breast cancer
Xiong T, et al.
Oncology Letters, 15(5), 7817-7827 (2018)
The role of RNA-binding protein tristetraprolin in cancer and immunity
Guo J, et al.
Medical Oncology (Northwood, London, England), 34(12), 196-196 (2017)
The RNA binding protein tristetraprolin down-regulates autophagy in lung adenocarcinoma cells
Dong F, et al.
Experimental Cell Research, 367(1), 89-96 (2018)
The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin
Wu X, et al.
PLoS Genetics, 14(5), e1007366-e1007366 (2018)
ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity
Moore MJ, et al.
eLife, 7, e33057-e33057 (2018)
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