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Merck
CN

SAB4200672

Monoclonal Anti-CDH13 antibody produced in mouse

clone CAD-5, purified from hybridoma cell culture

Synonym(s):

Anti-CDHH, Anti-Cadherin 13, Anti-P105

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About This Item

NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
CAD-5, monoclonal
Application:
immunoblotting
immunohistochemistry
immunoprecipitation (IP)
Species reactivity:
human
Citations:
2
Technique(s):
immunoblotting: 5-10 μg/mL using whole extract of human HeLa cells.
immunohistochemistry: 5-10 μg/mL using Biotin/ExtrAvidin®-Peroxidase staining system of heat-retrieved formalin-fixed, paraffin-embedded human heart sections
immunoprecipitation (IP): 5-10 μg/mL using whole extract of human HeLa cells.
Uniprot accession no.:
P55290

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Product Name

Monoclonal Anti-CDH13 antibody produced in mouse, clone CAD-5, purified from hybridoma cell culture

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

CAD-5, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

~1 mg/mL

technique(s)

immunoblotting: 5-10 μg/mL using whole extract of human HeLa cells.
immunohistochemistry: 5-10 μg/mL using Biotin/ExtrAvidin®-Peroxidase staining system of heat-retrieved formalin-fixed, paraffin-embedded human heart sections
immunoprecipitation (IP): 5-10 μg/mL using whole extract of human HeLa cells.

isotype

IgG1

UniProt accession no.

P55290

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... CDH13(1012)

Application

Monoclonal Anti-CDH13 antibody produced in mouse may be used in:
  • immunoblotting
  • immunoprecipitation
  • immunohistochemistry

Biochem/physiol Actions

Cadherin (CDH) is involved in mediating Ca2+-dependent cell-cell adhesion. Abnormalities in the CDH13 gene have been identified in human malignancies. Promoter methylation of CDH13 results in gene silencing in non-small cell lung carcinoma (NSCLC). CDH13 is involved in cell migration, axon guidance and neurite growth. It is also associated with attention-deficit/hyperactivity disorder (ADHD). CDH13 is also involved in autism spectrum disorders, bipolar disorder, schizophrenia and depression.
Monoclonal Anti-CDH13 recognizes human Cadherin 13.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-CDH13 (mouse IgG1 isotype) is derived from the hybridoma CAD-5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Cadherin 13 (CDH13) is a member of the cadherins multigene family of single-chain glycoprotein receptors. It is a glycosylphosphatidylinositol (GPI)- anchored member and a low-density lipoprotein (LDL)-binding protein usually found in smooth muscle. CDH13 is present in the brain and cardiovascular system. It is mapped on the human chromosome at 16q23.3.

Immunogen

N-terminal His-tagged recombinant protein of human Cadherin 13

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide

Preparation Note

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Legal Information

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
036M2708V

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Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition
Rivero O, et al.
Translational Psychiatry, 5(10), e655-e655 (2015)
Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations
Org E, et al.
Human Molecular Genetics, 18(12), 2288-2296 (2009)

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