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Merck
CN

SAB4200717

Anti-Troponin T antibody, Mouse monoclonal

clone JLT-12, purified from hybridoma cell culture

Synonym(s):

Anti-TNNT1, Anti-TNNT2

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-Troponin T antibody, Mouse monoclonal, clone JLT-12, purified from hybridoma cell culture

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

JLT-12, monoclonal

form

buffered aqueous solution

mol wt

antigen ~38 kDa

species reactivity

rat, human, mouse, bovine, rabbit, goat

concentration

~1.0 mg/mL

technique(s)

immunoblotting: 0.5-1 μg/mL using rat skeletal muscle extract
immunofluorescence: suitable
immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human skeletal muscle sections

isotype

IgG1

UniProt accession no.

P13805

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... TNNT1(7138)

Application

  • Anti-Troponin T antibody, Mouse monoclonal has been used in:
  • immunoblotting
  • immunofluorescence
  • immunohistochemistry

Biochem/physiol Actions

Troponin T (TNNT) participates in calcium regulation of actin thin filament function and is required for the contraction of striated muscles. Levels of cardiac Troponin T serve as a sensitive biomarker of myocardial injury. Troponin T has also been suggested as a potential marker in diagnosis of skeletal myopathies including amyotrophic lateral sclerosis (ALS).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Anti-Troponin T antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the JLT-12 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with purified Troponin T from rabbit skeletal muscle. Troponin T (TNNT) is the tropomyosin binding subunit of the troponin complex. Three genes have evolved to encode the cardiac (TNNT2), slow (TNNT1) and fast (TNNT3) skeletal muscle Troponin T proteins, which are specifically expressed in cardial, slow and fast skeletal muscles, respectively.

Immunogen

purified Troponin T from rabbit skeletal muscle

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000445897
0000445897
0000414619
0000414619
0000394938

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Amyotrophic lateral sclerosis (ALS), a novel rare cause of elevated plasma troponin T levels
Von LTG, et al.
Clinical Laboratory (2011)
The troponin complex and regulation of muscle contraction
Farah CS, et al.
Faseb Journal, 9(9), 755-767 (1995)
Elevation of cardiac troponin T in patients with amyotrophic lateral sclerosis
Mach L, et al.
Acta Neurologica Belgica, 116(4) (2016)
Cardiac troponin T and fast skeletal muscle denervation in ageing
Xu Z, et al.
Journal of Cachexia, Sarcopenia and Muscle, 8(5), 808-808 (2017)
TNNT1, TNNT2, and TNNT3: Isoform Genes, Regulation, and Structure-Function Relationships.
Wei B and Jin J P
Gene, 582(1), 1-13 (2016)

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