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Merck
CN

SAB4200730

Anti-Connexin 43 Antibody

mouse monoclonal, CXN-6

Synonym(s):

Anti-AVSD3, Anti-CMDR, Anti-CX43, Anti-EKVP, Anti-EKVP3, Anti-GJAL, Anti-HLHS1, Anti-HSS, Anti-ODDD, Anti-PPKCA

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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Product Name

Anti-Connexin 43 antibody, Mouse monoclonal, clone CXN-6, hybridoma cell culture supernatant

biological source

mouse

antibody form

culture supernatant

antibody product type

primary antibodies

clone

CXN-6, monoclonal

form

buffered aqueous solution

species reactivity

chicken, rat, feline, bovine, human, porcine, mouse

packaging

antibody small pack of 25 μL

concentration

~1.0 mg/mL

technique(s)

immunoblotting: 1:5,000-1:7,500 using mouse myoblast C2C12 cell line extract
immunofluorescence: 1:500-1:1,000 using mouse myoblast C2C12 cell line
immunohistochemistry: 1:200-1:500 using heat-retrieved formalin-fixed, paraffin-embedded mouse heart sections

isotype

IgM

UniProt accession no.

P17302

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

bovine ... Gja1(281193)
cat ... Gja1(101100211)
chicken ... Gja1(395278)
human ... GJA1(2697)
mouse ... Gja1(14609)
rat ... Gja1(24392)

Biochem/physiol Actions

Connexin 43 (Cx43) function is controlled by phosphorylation, SUMOylation and ubiquitination. The C-terminal tail of Cx43 modulates cytoskeletal dynamics and cell migration properties. Mutation in Cx43 leads to dysfunction of channel regulation domain and is associated with pathogenesis of hypoplastic left heart syndrome (HLHS). Cx43 dysregulation in testis contributes to infertility and testicular tumor. A gene mutation in the Cx43 results in abnormal development of eyes and teeth in oculodentodigital dysplasia (ODDD) , craniometaphyseal dysplasia and sudden infant death syndrome. Mutations in the GJA1 results in abnormal facial and skull development in hallermann-streiff syndrome (HSS). Missense mutations in GJA1 gene is also implicated in skin disorder called the, erythrokeratodermia variabilis et progressiva (EKVP)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Connexin 43 (Cx43) is also known as gap junction alpha-1 protein (GJA1). It is mapped to human chromosome 6q22.31. Cx43 is membrane protein with four transmembrane spanning regions, which comprise the gap junction channel. The loop connecting the transmembrane regions play a key role in channel docking. The N- and C-terminal amino acids are exposed to cytoplasm.

Immunogen

synthetic peptide from the C-terminal region of Connexin 43 protein, conjugated to KLH

Physical form

The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains bovine serum albumin and a human-derived protein.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

高风险级别生物产品--人源产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000267457
0000089485
0000267457
0000089485
079M4854V

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Dominant de novo mutations in GJA1 cause erythrokeratodermia variabilis et progressiva, without features of oculodentodigital dysplasia
Boyden LM, et al.
The Journal of Investigative Dermatology, 135(6), 1540-1547 (2015)
The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation
Kjenseth A, et al.
The Journal of Biological Chemistry, 287(19), 15851-15861 (2012)
Identification of connexin43 (alpha1) gap junction gene mutations in patients with hypoplastic left heart syndrome by denaturing gradient gel electrophoresis (DGGE)
Dasgupta C, et al.
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 479(1), 173-186 (2001)
Yan Zeng et al.
Cell & bioscience, 12(1), 191-191 (2022-12-03)
Mechanical loading promotes bone formation and osteocytes are a major mechanosensory cell in the bone. Both Piezo1 channels and connexin 43 hemichannels (Cx43 HCs) in osteocytes are important players in mechanotransduction and anabolic function by mechanical loading. However, the mechanism
Structural organization of gap junction channels
Sosinsky GE and Nicholson BJ
Biochimica et Biophysica Acta - Biomembranes, 1711(2), 99-125 (2005)
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