SAB4200790
Anti-Human IgG (Fc specific)-Peroxidase antibody, Mouse monoclonal
clone GG-7, purified from hybridoma cell culture
Synonym(s):
Anti-Human immunoglobulin G
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
peroxidase conjugate
Clone:
GG-7, monoclonal
Application:
ELISA (d)
Citations:
-
biological source
mouse
Quality Segment
conjugate
peroxidase conjugate
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
GG-7, monoclonal
form
lyophilized powder
species reactivity
human
technique(s)
direct ELISA: 1:40,000-1:80,000 using 2.5 μg/mL human IgG1 for coating
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
IgGs are the most common Immunoglobulins isotype in blood, lymph fluid, cerebrospinal fluid, and peritoneal fluid and a key players in the humoral immune response. IgGs include four subclasses (IgG1, IgG2, IgG3, and IgG4), they consist of a variable Fab fragment (which includes the antibody recognition site), and a conserved Fc fragment. The IgG subclasses differ in their physical and chemical properties, their distribution pattern is found to be age-dependent and every subclass has a specific biological function. IgG deficiencies are often associated with various diseases.
The Fc fragment has various important functions such as complement fixation, site for rheumatoid factor (autoantibody directed to Fc) attachment, passage through the placental membrane and protein A binding. A certain population of lymphocytes also possess an "Fc receptor". These functions indicate the importance of immunoreagents specific for the Fc fragment of Human IgG.
Monoclonal Anti-Human IgG (Fc specific) is specific for the Fc fragment of Human IgG and is observed with all human IgG subclasses but not with the Fab fragment of human IgG, purified light chains, human IgA or human IgM.
The Fc fragment has various important functions such as complement fixation, site for rheumatoid factor (autoantibody directed to Fc) attachment, passage through the placental membrane and protein A binding. A certain population of lymphocytes also possess an "Fc receptor". These functions indicate the importance of immunoreagents specific for the Fc fragment of Human IgG.
Monoclonal Anti-Human IgG (Fc specific) is specific for the Fc fragment of Human IgG and is observed with all human IgG subclasses but not with the Fab fragment of human IgG, purified light chains, human IgA or human IgM.
Immunogen
Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads.
Application
The antibody is recommended to use in various immunological techniques, including ELISA.
Physical form
Supplied as a lyophilized powder
Other Notes
This product is for R&D use only, not for drug, household, or other uses.
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Warning
hcodes
Hazard Classifications
Skin Sens. 1
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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