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Merck
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SAB4300031

Anti-phospho-GATA1 (pSer310) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-ERYF1 antibody produced in rabbit, Anti-GATA binding protein 1 (globin transcription factor 1) antibody produced in rabbit, Anti-GF-1 antibody produced in rabbit, Anti-GF1 antibody produced in rabbit, Anti-NFE1 antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02096392

Key Documents

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Product Name

Anti-phospho-GATA1 (pSer310) antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~43 kDa

species reactivity

rat, mouse, human

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(K-A-SP-G-K)

NCBI accession no.

NP_002040.1

UniProt accession no.

P15976

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer310)

Quality Level

100

Gene Information

human ... GATA1(2623)

Related Categories

Biochem/physiol Actions

GATA binding protein 1 (GATA1) plays a crucial role in erythroid and megakaryocyte differentiation and proliferation. It modulates the expression of genes and acts as an E-cadherin repressor. Mutations in the GATA1 gene have been linked to transient abnormal myelopoiesis (TAM) and myeloid leukemia of DS (ML-DS). The protein has anti-apoptotic functions in breast cancer.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

GATA binding protein 1 (GATA1) is a key hematopoietic transcription factor. It is encoded by the gene mapped to human chromosome Xp11.23 and it belongs to the GATA transcription factor family.
GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.

Immunogen

Peptide sequence around phosphorylation site of serine 310 (K-A-S(p)-G-K), according to the protein GATA1.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
511711042

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GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling.
Li Y
Oncotarget, 6, 4345-4356 (2015)
GATA1 mutations in a cohort of Malaysian children with Down syndrome-associated myeloid disorder.
Lum SH
Singapore Medical Journal, 57, 320-324 (2016)

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