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SAB4300192

Sigma-Aldrich

Anti-phospho-BRCA1 (pSer1423) antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Anti-BRCAI antibody produced in rabbit, Anti-BRCC1 antibody produced in rabbit, Anti-IRIS antibody produced in rabbit, Anti-PSCP antibody produced in rabbit, Anti-breast cancer 1, early onset antibody produced in rabbit
MDL number:
MFCD01092286
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~220 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(H-G-SP-Q-P)

NCBI accession no.

NP_009225.1

UniProt accession no.

P38398

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer1423)

Gene Information

human ... BRCA1(672)

Immunogen

Peptide sequence around phosphorylation site of serine 1423 (H-G-S(p)-Q-P), according to the protein BRCA1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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