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SAB4300396

Anti-CHUK (Ab-23) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-IKBKA antibody produced in rabbit, Anti-IKK-alpha antibody produced in rabbit, Anti-IKK1 antibody produced in rabbit, Anti-IKKA antibody produced in rabbit, Anti-conserved helix-loop-helix ubiquitous kinase antibody produced in rabbit

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02096685
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p), WB
Citations:
-
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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~85 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(L-G-T-G-G)

NCBI accession no.

NP_001269.3

UniProt accession no.

O15111

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CHUK(1147)

General description

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

Immunogen

Peptide sequence around aa. 21-25 (L-G-T-G-G), according to the protein CHUK.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
871521123

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Global Trade Item Number

SKUGTIN
SAB4300396-100UG04061831497021