SAB4300397
Anti-MYOD1 (Ab-200) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-MYF3 antibody produced in rabbit, Anti-MYOD antibody produced in rabbit, Anti-PUM antibody produced in rabbit, Anti-bHLHc1 antibody produced in rabbit, Anti-myogenic differentiation 1 antibody produced in rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~40 kDa
species reactivity
mouse, human, rat
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(A-S-S-P-R)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MYOD1(4654)
General description
MYOD1 (myogenic differentiation 1) gene codes for a nuclear protein, that is a member of the basic helix-loop-helix (bHLH) family of transcription factors and the myogenic factors subfamily. It is located on human chromosome 11p15.1.
MyoD encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis.
Immunogen
Peptide sequence around aa. 198!202 (A-S-S-P-R), according to the protein MYOD1.
Biochem/physiol Actions
Lack of MyoD (myogenic differentiation) results in a perinatally lethal fetal akinesia. It brings histone-modifying enzymes, which help to induce muscle differentiation.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Deficiency of the myogenic factor MyoD causes a perinatally lethal fetal akinesia
Watson CM, et al.
Journal of medical Genetics, 53(4), 264-269 (2016)
Katalin Gyurina et al.
International journal of molecular sciences, 24(23) (2023-12-09)
Stimulation of thermogenesis by inducing uncoupling protein 1 (UCP1) expression in adipocytes is thought to promote weight loss by increasing energy expenditure, and it is postulated that the human newborn has thermogenic subcutaneous fat depots. However, it remains unclear whether
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations
Kohsaka S, et al.
Nature Genetics, 46(6), 595-600 (2014)
Narasimhan P Agaram et al.
Genes, chromosomes & cancer, 53(9), 779-787 (2014-05-16)
Sclerosing and spindle cell rhabdomyosarcoma (RMS) are rare types of RMS recently reclassified as a stand-alone pathologic entity, separate from embryonal RMS (ERMS). Although sclerosing and spindle cell RMS share clinical and morphologic features, a pathogenetic link based on shared
Manuela Dos Santos et al.
Advances in rheumatology (London, England), 62(1), 27-27 (2022-07-23)
Clinical evidence of skeletal muscle involvement is not uncommon in systemic lupus erythematosus (SLE). Because of the poor understanding of signaling pathways involved in SLE muscle wasting, the aim of this study was to evaluate the effects of vitamin D supplementation
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