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Merck
CN

SAB4300490

Anti-BRCA1 (Ab-1423) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-BRCAI antibody produced in rabbit, Anti-BRCC1 antibody produced in rabbit, Anti-IRIS antibody produced in rabbit, Anti-PSCP antibody produced in rabbit, Anti-breast cancer 1, early onset antibody produced in rabbit

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About This Item

MDL number:
MFCD01092286
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~220 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(H-G-S-Q-P)

NCBI accession no.

NP_009225.1

UniProt accession no.

P38398

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BRCA1(672)

Related Categories

General description

BRCA1 (breast cancer 1) is a tumor suppressor gene, that is located on human chromosome 17q21. It has an N-terminal RING (really interesting new gene) domain, a negatively charged region in its C terminus, and C-terminal sequences partially homologous to yeast RAD9.
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation.

Immunogen

Peptide sequence around aa. 1421-1425 (H-G-S-Q-P), according to the protein BRCA1.

Biochem/physiol Actions

BRCA1 (breast cancer 1) mutation carriers are expected to get breast and ovarian cancer. It is involved in several cellular processes like transcription regulation, DNA damage repair and protein ubiquitination. Interaction of BRCA1 with PABP1 (poly(A)-binding protein 1) helps to control protein synthesis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
951421234

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Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium
Easton DF, et al.
American Journal of Human Genetics, 56(1), 265-271 (1995)
Association of BRCA1 with Rad51 in mitotic and meiotic cells
Scully R, et al.
Cell, 88(2), 265-275 (1997)
BRCA1-Dependent Translational Regulation in Breast Cancer Cells
Dacheux E, et al.
PLoS ONE, 8(6) (2013)
Jing Yang et al.
International journal of biological sciences, 17(12), 3239-3254 (2021-08-24)
Breast cancer susceptibility gene 1 (BRCA1) encodes a tumor suppressor that is frequently mutated in familial breast and ovarian cancer patients. BRCA1 functions in multiple important cellular processes including DNA damage repair, cell cycle checkpoint activation, protein ubiquitination, chromatin remodeling

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