SAB4300525
Anti-GAP43 (Ab-41) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-B-50 antibody produced in rabbit, Anti-PP46 antibody produced in rabbit, Anti-growth associated protein 43 antibody produced in rabbit
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC (p), WB
Citations:
10
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~43 kDa
species reactivity
rat, human, mouse
concentration
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(Q-A-S-F-R)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GAP43(2596)
General description
GAP43 encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Growth associated protein-43 (GAP-43) is a phosphoprotein associated with membrane. It is located on chromosome 3q13. During neural development and axonal regeneration, GAP43 is upregulated in neuronal growth cones and Schwann cell precursors.
Immunogen
Peptide sequence around aa. 38-43 (Q-A-S-F-R), according to the protein GAP43.
Biochem/physiol Actions
Growth associated protein-43 (GAP-43) participates in neurite outgrowth, growth cone navigation, neurotransmission, stabilization of axonal branches and synaptic plasticity. In humans and mice, GAP43 is recognized as a possible gene for autism and autistic-like disorders.
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Víctor Carriel et al.
Journal of tissue engineering and regenerative medicine, 11(2), 553-563 (2014-08-02)
Nerve conduits are promising alternatives for repairing nerve gaps; they provide a close microenvironment that supports nerve regeneration. In this sense, histological analysis of axonal growth is a determinant to achieve successful nerve regeneration. To evaluate this process, the most-used
Ryan L O'Hare Doig et al.
Frontiers in molecular neuroscience, 13, 85-85 (2020-07-17)
Reducing the extent of secondary degeneration following spinal cord injury (SCI) is necessary to preserve function, but treatment options have thus far been limited. A combination of the ion channel inhibitors Lomerizine (Lom), YM872 and oxATP, to inhibit voltage-gated Ca2+
Jesús Chato-Astrain et al.
Frontiers in cellular neuroscience, 12, 501-501 (2019-01-11)
The regenerative capability of peripheral nerves is very limited, and several strategies have been proposed to increase nerve regeneration. In the present work, we have analyzed the in vivo usefulness of a novel nanostructured fibrin-agarose bio-artificial nerve substitute (Nano) used
A rare 3q13.31 microdeletion including GAP43 and LSAMP genes
Gimelli S, et al.
Molecular Cytogenetics, 6(1), 52-52 (2013)
Jesús Chato-Astrain et al.
Neural regeneration research, 18(8), 1852-1856 (2023-02-09)
Growth-associated protein 43 plays a key role in neurite outgrowth through cytoskeleton remodeling. We have previously demonstrated that structural damage of peripheral nerves induces growth-associated protein 43 upregulation to promote growth cone formation. Conversely, the limited regenerative capacity of the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4300525-100UG | 04061833477267 |
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