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Merck
CN

SAB4300627

Anti-CCR7 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-BLR2, Anti-CD197, Anti-CDw197, Anti-CMKBR7, Anti-EBI1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
human
Citations:
3
Technique(s):
western blot: 1:500-1:1000
Uniprot accession no.:
P32248

Key Documents

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Product Name

Anti-CCR7 antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~43 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(T-D-D-Y-I)

NCBI accession no.

NM_001838.3

UniProt accession no.

P32248

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CCR7(1236)

Related Categories

Biochem/physiol Actions

CCR7 (C-C motif chemokine receptor 7) regulates lymphocyte cell trafficking and lymph node distribution. CCR7′s interaction with CCL21 promotes metastasis of cancer via lymph node. CCR7 is known to be associated with breast cancer, melanoma, colorectal cancer, non-small cell lung cancer, and chronic lymphocytic leukemia.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Anti-CCR7 antibody detects endogenous level of total CCR7(CD197) protein. CCR7 (C-C motif chemokine receptor 7) is localized to T cells, natural killer and dendritic cells. The CCR7 gene is mapped to human chromosome 17q21.2.
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Immunogen

Peptide sequence around aa. 29-33 (T-D-D-Y-I), according to the protein NP_001829.1

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Confirmation of novel type 1 diabetes risk loci in families.
Cooper J D, et al.
Diabetologia, 55(4), 996-1000 (2012)
Association of CXCR4, CCR7, VEGF-C and VEGF-D expression with lymph node metastasis in patients with cervical cancer.
Dai Y, et al.
Eur. J. Obstet. Gyn. Rep. Biol., 214, 178-183 (2017)
Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization.
Tejchman A, et al.
Oncotarget, 8(19), 31876-31876 (2017)

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