SAB4300641
Anti-ABL1/2 (Ab-393/429) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-ABL, Anti-JTK7, Anti-c-ABL, Anti-p150, Anti-v-abl
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
-
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
135-210 kDa
species reactivity
human, mouse
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(D-T-Y-T-A)
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ABL1(25), ABL2(27)
mouse ... ABL1(11350), ABL2(11352)
General description
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
The antibody detects endogenous levels of total ABL1/2 protein.
Immunogen
Peptide sequence around aa. 391-395 (D-T-Y-T-A), according to the protein NP_005148.2, NP_001129472.1
Features and Benefits
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Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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