SAB4300781
Anti-SLCO1B1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
LST-1, Liver-specific organic anion transporter 1, OATP 2, Sodium-independent organic anion-transporting polypeptide 2, Solute carrier family 21 member 6
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About This Item
NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
6
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
76 kDa
species reactivity
human
concentration
1.0 mg/mL
technique(s)
western blot: 1:500-1:3000 (Cell Lysate)
isotype
IgG
accession no.
NP_006437.3
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLCO1B1(10599)
General description
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) or liver-specific organic anion transporter 1 (LST-1) and sodium-independent organic anion-transporting polypeptide 2 (OATP-2), is formerly known as solute carrier family 21 (organic anion transporter), member 6 (SLC21A6). SLCO1B1 is predominantly expressed in liver. It is expressed in the basolateral membrane. It has 12 transmembrane domains. In human chromosome, the gene SLCO1B1 is localized on 12p12.1
Immunogen
Synthesized peptide derived from internal of human SLCO1B1.
Biochem/physiol Actions
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) transports taurocholate, conjugated steroids, eicosanoids, and thyroid hormones, in a sodium independent manner. SLCO1B1 is the key transporter of bile for the clearance of human liver. Polymorphism in SLCO1B1 might lead to life threatening drug toxicities. Mutations in SLCO1B1 and SLCO1B3 leads to rotor syndrome in human, affecting conjugated bilirubin reuptake in liver. Genetic variability in SLCO1B1 affects the plasma concentration of statins.
The antibody detects endogenous levels of total SLCO1B1 protein.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
低风险生物材料
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The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy
Wilke RA, et al.
Clinical Pharmacology and Therapeutics, 92(1), 112-117 (2012)
Integrative genomics strategies to elucidate the complexity of drug response
Kasarskis A, et al.
Pharmacogenomics, 12(12), 1695-1715 (2011)
Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
Abe T, et al.
The Journal of Biological Chemistry, 274(24), 17159-17163 (1999)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4300781-100UL | 04061837444654 |