SAB4300781
Anti-SLCO1B1 antibody produced in rabbit
affinity isolated antibody
别名:
LST-1, Liver-specific organic anion transporter 1, OATP 2, Sodium-independent organic anion-transporting polypeptide 2, Solute carrier family 21 member 6
产品名称
Anti-SLCO1B1 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
76 kDa
species reactivity
human
concentration
1.0 mg/mL
technique(s)
western blot: 1:500-1:3000 (Cell Lysate)
isotype
IgG
accession no.
NP_006437.3
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLCO1B1(10599)
Biochem/physiol Actions
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) transports taurocholate, conjugated steroids, eicosanoids, and thyroid hormones, in a sodium independent manner. SLCO1B1 is the key transporter of bile for the clearance of human liver. Polymorphism in SLCO1B1 might lead to life threatening drug toxicities. Mutations in SLCO1B1 and SLCO1B3 leads to rotor syndrome in human, affecting conjugated bilirubin reuptake in liver. Genetic variability in SLCO1B1 affects the plasma concentration of statins.
The antibody detects endogenous levels of total SLCO1B1 protein.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) or liver-specific organic anion transporter 1 (LST-1) and sodium-independent organic anion-transporting polypeptide 2 (OATP-2), is formerly known as solute carrier family 21 (organic anion transporter), member 6 (SLC21A6). SLCO1B1 is predominantly expressed in liver. It is expressed in the basolateral membrane. It has 12 transmembrane domains. In human chromosome, the gene SLCO1B1 is localized on 12p12.1
Immunogen
Synthesized peptide derived from internal of human SLCO1B1.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Integrative genomics strategies to elucidate the complexity of drug response
Kasarskis A, et al.
Pharmacogenomics, 12(12), 1695-1715 (2011)
The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy
Wilke RA, et al.
Clinical Pharmacology and Therapeutics, 92(1), 112-117 (2012)
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
Ko?nig J, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 278(1), G156-G164 (2000)
Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
Abe T, et al.
The Journal of Biological Chemistry, 274(24), 17159-17163 (1999)
Evita van de Steeg et al.
The Journal of clinical investigation, 122(2), 519-528 (2012-01-11)
Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood, resulting in jaundice. The mechanistic basis of bilirubin excretion
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