SAB4300830
Anti-UCN antibody produced in rabbit
affinity isolated antibody
Synonym(s):
UI, UROC
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Anti-UCN antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
concentration
0.7 mg/mL
technique(s)
immunohistochemistry: 1:25- 1:100
isotype
IgG
accession no.
NP_003344.1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... UCN(7349)
Application
Anti-UCN antibody produced in rabbit has been used in immunohistochemical analysis.
Biochem/physiol Actions
The antibody detects endogenous levels of total UCN protein.
Urocortin (UCN1) is a key protein involved in regulating hypothalamic-pituitary-adrenal axis and modulating stress responses. Ucn1 is associated with both G-protein coupled CRF receptors and CRF binding proteins. UCN increases the heart rate, cardiac output, and coronary blood flow according to the dosage. UCN protects cardiac myocytes from cell death due to stress. Ucn upregulates p42/p44 mitogen activated protein kinase (MAPK) signalling pathway and protects the heart from reperfusion injury. High levels of Ucn mRNA have been observed in the Edinger−Westphal (EW) nucleus, associated with alcohol and drug addiction. Ucn delays the gastric emptying and reduces the food intake and thus regulates the body weight. Ucn enhances anxiogenic-like or stress-like effect. Ucn causes degranulation of mast cells and increases vascular permeability in response to stress. Ucn is found to be associated with stress induced atopic dermatitis or psoriasis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Urocortin (UCN) belongs to the hypothalamic hormone corticotrophin-releasing factor (CRF) family. UCN has 45% homology to CRF. UCN is expressed in brain, placenta, lymphocytes and heart. In human chromosome, the gene UCN is localized on 2p23.3.
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human urocortin
Physical form
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice
Asakawa A, et al.
Gastroenterology, 116(6), 1287-1292 (1999)
Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system
Giardino WJ, et al.
Translational Psychiatry, 7(1), e1021-e1021 (2017)
Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway
Brar BK, et al.
The Journal of Biological Chemistry, 275(12), 8508-8514 (2000)
Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors
Singh LK, et al.
Journal of Pharmacology and Experimental Therapeutics, 288(3), 1349-1356 (1999)
Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway
Schulman D, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 52(4), H1481-H1488 (2002)
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