SAB4301270
Anti-phospho-Nuclear Receptor NR4A1 (pSer351) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
GFRP1, HMR, NAK1, NGFIB, NR4A1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
64 kDa
species reactivity
rat, human, mouse
concentration
1.0 mg/mL
technique(s)
immunohistochemistry: 1:50-1:100
isotype
IgG
accession no.
NP_002126.2.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer351)
Gene Information
human ... NR4A1(3164)
General description
Nuclear receptor subfamily 4 group A member 1 (NR4A1) also known as nuclear hormone receptor 77 (NUR77), belongs to NR4A subfamily nuclear hormone receptors. In human chromosome, the gene NR4A1 is localized on 12q13.13.
Immunogen
Peptide sequence around phosphorylation site of Serine351(L-P-S(p)-K-P) derived from Human Nuclear Receptor NR4A1.
Biochem/physiol Actions
Nuclear receptor subfamily 4 group A member 1 (NR4A1) is essential for regulation of cell proliferation, apoptosis and energy metabolism. Nur77 is an acetylated protein, modulated by histone acetyltransferase p300 (p300) and histone deacetylase 1 (HDAC1) for its rapid turnover. Nur77 regulates liver kinase B1 (LKB1)- AMP (adenosine monophosphate)-activated protein kinase (AMPK) and plays a major role in glucose metabolism. Expression of Nur77 in skeletal muscle promotes glucose uptake by enhancing insulin pathway and upregulates glycolysis pathway. Expression of Nur77 in hepatocytes promotes gluconeogenesis. Mutation in Nur77 may result in diet-induced obesity and insulin resistance in tissues. Nur77 is a potential drug target for metabolic disorders. NR4A1 is an anti-oncogenic protein that reduces the tumour cell proliferation and metastasis. NR4A1 increases the gastric cancer cells sensitivity towards tumour necrosis factor α (TNF-α) mediated apoptotic pathway. NR4A1 is downregulated in breast cancer, leukemia. NR4A1 plays a crucial role and a potent therapeutic target for fibrosis of endometriosis.
The antibody detects endogenous levels of Nuclear Receptor NR4A1 only when phosphorylated at serine 351
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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NR4A1-induced increase in the sensitivity of a human gastric cancer line to TNF alpha-mediated apoptosis is associated with the inhibition of JNK/Parkin-dependent mitophagy
Yan H, et al.
International Journal of Oncology, 52(2), 367-378 (2018)
NR4A1 is Involved in Fibrogenesis in Ovarian Endometriosis
Zeng X, et al.
Cellular Physiology and Biochemistry, 46(3), 1078-1090 (2018)
Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1
Kang SA, et al.
Biochemical Pharmacology, 80(6), 867-873 (2010)
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Zhan YY, et al.
Nature Chemical Biology, 8(11), 897-904 (2012)
Merlin G Butler et al.
International journal of molecular sciences, 16(3), 6464-6495 (2015-03-25)
Recently, autism-related research has focused on the identification of various genes and disturbed pathways causing the genetically heterogeneous group of autism spectrum disorders (ASD). The list of autism-related genes has significantly increased due to better awareness with advances in genetic
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