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SAB4301310

Anti-phospho-PEK/PERK (pThr981) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

E2AK3, EIF2AK3, PEK, PERK

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-phospho-PEK/PERK (pThr981) antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

125 kDa

species reactivity

human

concentration

1.0 mg/mL

technique(s)

immunohistochemistry: 1:50-1:100

isotype

IgG

accession no.

NP_004827.4.

UniProt accession no.

Q9NZJ5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr981)

Quality Level

100

Gene Information

human ... EIF2AK3(9451)

Biochem/physiol Actions

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) helps to detect the protein-folding imbalance created by endoplasmic reticulum (ER) stress. EIF2AK3 works as an endoplasmic reticulum (ER) stress sensor to modulate global protein synthesis. Mutation in EIF2AK3 gene results in Wolcott-rallison syndrome.
The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)/EIF2AK3 (eukaryotic translation initiation factor 2 α kinase 3) is a type I transmembrane protein, located on ER (endoplasmic reticulum). It is a member of the eIF2α kinase subfamily. This gene is located on human chromosome 2p. EIF2AK3 has 16 exons and is made of cytoplasmic and kinase domains.

Immunogen

Peptide sequence around phosphorylation site of threonine 981(A-R-H(p)-T-G) derived from Human PEK/PERK.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
461211751

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The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins.
Wang P, et al.
Acta crystallographica. Section D, Structural biology, 72(12), 1290-1297 (2016)
Monogenic diabetes in children and young adults: Challenges for researcher, clinician and patient.
Slingerland AS.
Reviews in Endocrine & Metabolic Disorders, 7(3), 171-185 (2006)
Wolcott-Rallison Syndrome with Novel EIF2AK3 Gene Mutation.
Gurbuz F, et al.
Journal of Clinical Research in Pediatric Endocrinology, 8(4), 496-496 (2016)
A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density.
Liu J, et al.
Journal of Bone and Mineral Research, 27(2), 331-341 (2012)
Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate.
Liu Z, et al.
Cell Death & Disease, 6(7), e1822-e1822 (2015)
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