SAB4301658
Anti-CSPG4 Antibody
rabbit polyclonal
Synonym(s):
HMW-MAA, MCSP, MCSPG, MSK16, NG2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Product Name
Anti-CSPG4, affinity isolated antibody
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human, mouse, rat
technique(s)
immunohistochemistry: 1:20-1:100
western blot: 1:500-1:2000
accession no.
NP_001888
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CSPG4(1464)
Physical form
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Biochem/physiol Actions
Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.
Features and Benefits
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General description
Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas
Eisenmann KM, et al.
Nature Cell Biology, 1(8), 507-513 (1999)
Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma
Wang J, et al.
PLoS ONE, 6(7), e23062-e23062 (2011)
A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family
Staub E, et al.
Febs Letters, 527(1-3), 114-118 (2002)
Gene expression signature associated with BRAF mutations in human primary cutaneous melanomas
Kannengiesser C, et al.
Molecular Oncology, 1(4), 425-430 (2008)
Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma
Svendsen A, et al.
Acta Neuropathologica, 122(4), 495-510 (2011)
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