Skip to Content
Merck
CN

SAB4500003

Anti-BCL-2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, BCL2

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

MDL number:
MFCD00239644
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 26 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P10415

UniProt accession no.

P10415

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BCL2(596)

General description

B-cell lymphoma 2 (BCL-2) is an integral inner mitochondrial membrane protein that acts as an antiapoptotic protein. It is a target gene of nuclear factor kappa B (NF-kB). The gene encoding BCL-2 is localized on human chromosome 18q21.

Immunogen

The antiserum was produced against synthesized peptide derived from human BCL-2.

Immunogen Range: 46-95

Application

Anti-BCL-2 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

BCL2 is an apoptosis regulator that is expressed in sub-cellular components such as the mitochondria and nucleus. While mitochondrial BCL2 inhibits apoptosis, BCL2 present in the nucleus may activate cell death. BCL2 may also regulate autophagy during starvation . Anti-BCL-2 antibodies are specific for endogenous levels of total BCL-2 protein in rats, humans and mice.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
424170774
210774

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Different signalling in infarcted and non-infarcted areas of rat failing hearts: A role of necroptosis and inflammation
Lichy M, et al.
Journal of Cellular and Molecular Medicine (2019)
Bcl-2 is a critical mediator of intestinal transformation.
Heijden M, et al.
Nature Communications (2016)
Analysis of necroptotic proteins in failing human hearts
Szobi A, et al.
Journal of Translational Medicine (2017)
Sevoflurane pretreatment attenuates hypoxia/
reoxygenation-induced cardiomyocyte apoptosis
through activation of AKT/pim-1 and AKT/GSK3?
signaling pathways
Zhao, et al.
Biotechnology, Biotechnological Equipment (2019)
Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.
Portier BP
The Journal of Biological Chemistry (2006)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service