SAB4500078
Anti-p15 INK antibody produced in rabbit
affinity isolated antibody
Synonym(s):
CDKN2B, CDN2B, Cyclin-dependent kinase 4 inhibitor B, MTS2, Multiple tumor suppressor 2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 14 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CDKN2B(1030)
General description
Anti-p15 INK Antibody detects endogenous levels of total p15 INK protein.
Cyclin-dependent kinase inhibitor 2B (CDKN2B) gene codes for tumor-suppressor p15INK4B protein. p15INK4B is a member of the INK4 family of protein kinase inhibitors. In bone marrow cells, p15INK4B expression is mainly seen at a high level in maturing monocytes/macrophages and lymphocytes. It is located in the nucleus and cytoplasm. The CDKN2B gene is mapped to human chromosome 9p21.3. Anti-p15 INK Antibody detects endogenous levels of total p15 INK protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human p15 INK.
Immunogen Range: 89-138
Immunogen Range: 89-138
Application
Anti-p15 INK antibody produced in rabbit has been used in western blot (1:500).
Biochem/physiol Actions
Cyclin-dependent kinase inhibitor 2B (CDKN2B) plays a key role in the cell cycle and senescence. It participates in the differentiation of the hematopoietic cell. CDKN2B gene is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL). Homozygous deletion of the CDKN2B gene or p15INK4B locus on chromosome results in glioblastoma multiforme (GBM). Silencing of p15INK4B is associated with myelodysplastic syndromes, leukemia, and myeloproliferative diseases.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4))
Fares J, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
Soon Sang Park et al.
Heliyon, 9(2), e13170-e13170 (2023-02-15)
Senescent tumor cells are nonproliferating tumor cells which are closely related to cancer progression by secreting senescence-related molecules, called senescence-associated secreting phenotypes. Therefore, the presence of senescent tumor cells is considered a prognostic factor in various cancer types. Although senescence-associated
Woori Jang et al.
Experimental & molecular medicine, 51(1), 1-15 (2019-01-13)
We identified principal genetic alterations in 97.1% (99/102) of patients with T-acute lymphoblastic leukemia (T-ALL) using integrative genetic analyses, including massive parallel sequencing and multiplex ligation-dependent probe amplification (MLPA). A total of 133 mutations were identified in the following genes
Martin S Minns et al.
The American journal of pathology, 186(2), 285-296 (2015-12-20)
The process of wound healing involves a complex network of signaling pathways working to promote rapid cell migration and wound closure. Activation of purinergic receptors by secreted nucleotides plays a major role in calcium mobilization and the subsequent calcium-dependent signaling
Anthony Lagnado et al.
The EMBO journal, 40(9), e106048-e106048 (2021-03-26)
Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro-inflammatory phenotype, thought to contribute to aging and age-related diseases. Neutrophils have essential roles in inflammatory responses; however, in certain contexts their abundance is associated with
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