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Merck
CN

SAB4500131

Anti-TRXR2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Selenoprotein Z, TR-β, Thioredoxin reductase 2, Thioredoxin reductase TR3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 56 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

Q9NNW7

UniProt accession no.

Q9NNW7

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TXNRD2(10587)

General description

Anti-TRXR2 Antibody detects endogenous levels of total TRXR2 protein.
Thioredoxin reductase 2 (TRXR2) is mitochondrial protein-disulfide oxidoreductase, encoded by the gene mapped to human chromosome 22q11.21. TRXR2 is one of the mammalian isoforms of thioredoxin reductase (TrxR).

Immunogen

The antiserum was produced against synthesized peptide derived from human TRXR2.

Immunogen Range: 471-520

Biochem/physiol Actions

Thioredoxin reductase 2 (TRXR2) regulates cell survival during mammalian embryonic development. In addition, it also regulates mitochondria-dependent apoptosis. TRXR2 also controls protein tyrosine phosphorylation and cell proliferation. The protein expression is associated with development of glioma. In humans, this enzyme stimulates the apoptosis in HeLa cells. Mutation in the gene might increase the risk of susceptibility to myocardial infarction (MI) in type 2 diabetes mellitus (T2DM) patients.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
310378

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Mitochondrial thioredoxin system effects of TrxR2 overexpression on redox balance, cell growth, and apoptosis.
Patenaude A, et al.
The Journal of Biological Chemistry, 279(26), 27302-27314 (2004)
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus
Kariz S, et al.
Diabetes Research and Clinical Practice, 108(2), 323-328 (2015)
The Genes Associated with RNA Editing and Glioma on the Chromosome 22q.
Wang G and Tian Y
Advances in Medical Sciences, 2(1) (2014)
Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation
Kim MR, et al.
Biochemical and Biophysical Research Communications, 304(1), 119-124 (2003)

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