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SAB4500223

Anti-MEKKK 1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
4

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 91 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000, western blot: 1:500-1:1000

NCBI accession no.

Q92918

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAP3K1(4214)

General description

Anti-MEKKK 1 Antibody detects endogenous levels of total MEKKK 1 protein. The MEKKK 1 (mitogen-activated protein kinase kinase kinase 1) gene is mapped to human chromosome 5q11.2 and codes for serine/threonine kinase protein containing a plant homeodomain.

Immunogen

The antiserum was produced against synthesized peptide derived from human MEKKK 1.

Immunogen Range: 371-420

Biochem/physiol Actions

MEKKK 1 (mitogen-activated protein kinase kinase kinase 1) controls different processes associated with inflammation and apoptosis. In response to upstream signals, the members of the MAPK (mitogen-activated protein kinase) family gets activated upon phosphorylation. MEKKK 1 possesses E3 ubiquitin ligase activity in relation to c-Jun protein stability and regulates the JNK (c-Jun NH2-terminal kinases) pathway. MEKKK 1 gene regulation is associated with acute respiratory distress syndrome.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
3111444

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A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11. 2 and 14q24. 1 (RAD51L1).
Thomas G, et al.
Nature Genetics, 41(5), 579-579 (2009)
CSN6 positively regulates c-Jun in a MEKK1-dependent manner.
Shin J, et al.
Cell Cycle, 14(19), 3079-3087 (2015)
Nuclear localization signal and p53 binding site in MAP/ERK kinase kinase 1 (MEKK1).
Chipps E, et al.
Journal of Cellular Biochemistry, 116(12), 2903-2914 (2015)
Genetic Variation in MAP3K1 Associates with Ventilator-Free Days in Acute Respiratory Distress Syndrome.
Morrell E D, et al.
American Journal of Respiratory Cell and Molecular Biology, 58(1), 117-125 (2018)

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