SAB4500223
Anti-MEKKK 1 antibody produced in rabbit
affinity isolated antibody
别名:
Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1
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NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 91 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MAP3K1(4214)
General description
Anti-MEKKK 1 Antibody detects endogenous levels of total MEKKK 1 protein. The MEKKK 1 (mitogen-activated protein kinase kinase kinase 1) gene is mapped to human chromosome 5q11.2 and codes for serine/threonine kinase protein containing a plant homeodomain.
Immunogen
The antiserum was produced against synthesized peptide derived from human MEKKK 1.
Immunogen Range: 371-420
Immunogen Range: 371-420
Biochem/physiol Actions
MEKKK 1 (mitogen-activated protein kinase kinase kinase 1) controls different processes associated with inflammation and apoptosis. In response to upstream signals, the members of the MAPK (mitogen-activated protein kinase) family gets activated upon phosphorylation. MEKKK 1 possesses E3 ubiquitin ligase activity in relation to c-Jun protein stability and regulates the JNK (c-Jun NH2-terminal kinases) pathway. MEKKK 1 gene regulation is associated with acute respiratory distress syndrome.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
CSN6 positively regulates c-Jun in a MEKK1-dependent manner.
Shin J, et al.
Cell Cycle, 14(19), 3079-3087 (2015)
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11. 2 and 14q24. 1 (RAD51L1).
Thomas G, et al.
Nature Genetics, 41(5), 579-579 (2009)
Nuclear localization signal and p53 binding site in MAP/ERK kinase kinase 1 (MEKK1).
Chipps E, et al.
Journal of Cellular Biochemistry, 116(12), 2903-2914 (2015)
Genetic Variation in MAP3K1 Associates with Ventilator-Free Days in Acute Respiratory Distress Syndrome.
Morrell E D, et al.
American Journal of Respiratory Cell and Molecular Biology, 58(1), 117-125 (2018)
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