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Merck
CN

SAB4500466

Anti-CRHR2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CRF-R 2, CRF2, CRH-R 2, Corticotropin-releasing factor receptor 2, Corticotropin-releasing hormone receptor 2

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-CRHR2 antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 47 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

Q13324

UniProt accession no.

Q13324

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CRHR2(1395)

Application

Anti-CRHR2 antibody has been used in immunoprecipitation and western blotting .{6,7}
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

CRHR2 (corticotropin releasing hormone receptor 2) is involved in the relaxation of smooth muscle response and may affect the response of acute airway bronchodilator to short acting β2 agonist treatment of asthma. Signaling pathways of CRHR2 modulate the hypothalamic-pituitary-adrenocortical axis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Anti-CRHR2 antibody detects endogenous levels of total CRHR2 protein.

The CRHR2 (corticotropin releasing hormone receptor 2) gene is a member of G protein coupled receptors (GPCRs) family. It is located on human chromosome 7p21-p15. It has 12 exons and approximately 50,000 base pairs (Kbp). It has 3 isoforms, such as CRHR2α β and γ out of which, CRHR2γ is mostly expressed in the brain and CRHR2α 2β are expressed in the brain and smooth muscle.

Immunogen

The antiserum was produced against synthesized peptide derived from human CRHR2.

Immunogen Range: 71-120

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
61073

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Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma
Poon AH, et al.
Pharmacogenetics and Genomics, 18, 373-382 (2008)
N Y Intekhab-Alam et al.
Cell death & disease, 4, e717-e717 (2013-07-13)
Osteoarthritis (OA) is characterized by a loss of joint mobility and pain resulting from progressive destruction and loss of articular cartilage secondary to chondrocyte death and/ or senescence. Certain stimuli including nitric oxide (NO) and the pro-inflammatory cytokine tumor necrosis
Katalin Eszter Ibos et al.
Pflugers Archiv : European journal of physiology, 476(2), 179-196 (2023-11-22)
Chronic kidney disease (CKD) is associated with anxiety; however, its exact mechanism is not well understood. Therefore, the aim of the present study was to assess the effect of moderate CKD on anxiety in rats. 5/6 nephrectomy was performed in

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