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Merck
CN

SAB4500631

Anti-CHOP, N-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(s):

C/EBP-homologous protein, DDIT3, DNA-damage inducible transcript 3, GADD153, Growth arrest and DNA-damage-inducible protein GADD153

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 19 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P35638

UniProt accession no.

P35638

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DDIT3(1649)

Related Categories

General description

Anti-CHOP Antibody detects endogenous levels of total CHOP protein.
CCAAT/enhancer-binding protein homologous protein (CHOP) is a transcriptional regulator, that is located on human chromosome 12q13. It is also known as DNA damage inducible transcript 3 (DDIT3).

Immunogen

The antiserum was produced against synthesized peptide derived from human CHOP.

Immunogen Range: 15-64

Application

Anti-CHOP, N-Terminal antibody has been used in protein extraction and western blotting.

Biochem/physiol Actions

CCAAT/enhancer-binding protein homologous protein (CHOP) controls endoplasmic reticulum (ER) stress-mediated apoptosis. It also modulates the transcription of cellular lipid metabolism. CHOP controls chronic kidney disease–induced vascular calcification.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
210863

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Contributions of cytogenetics and molecular cytogenetics to the diagnosis of adipocytic tumors
Nishio J
Journal of Biomedicine and Biotechnology (2011)
Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythematosus
Guo G, et al.,
Journal of immunology research (2015)
Endoplasmic reticulum stress effector CCAAT/enhancer-binding protein homologous protein (CHOP) regulates chronic kidney disease-induced vascular calcification
Miyazaki-Anzai S, et al.
Journal of the American Heart Association (2014)
C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis
Rahman K, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 96(8), 895-908 (2016)
Sujata Saraswat Ohri et al.
Journal of neurotrauma, 29(3), 579-588 (2011-09-22)
Manipulation of various components of the endoplasmic reticulum (ER) stress response (ERSR) has led to functional recovery in diabetes, cancer, and several neurodegenerative diseases, indicating its use as a potential therapeutic intervention. One of the downstream pro-apoptotic transcription factors activated
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