SAB4500869
Anti-CD32 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
CD32, CDW32, FC γ receptor IIB, FC-γ RII, FC-γ RII-B
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 34 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FCGR2B(2213)
General description
The human immune system has six FcγRs-FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA and FcγRIIIB. FcγRIIIB/CD32 (Fc fragment of IgG receptor IIb) is an inhibitory receptor that is located on human chromosome 1q23.
Anti-CD32 Antibody detects endogenous levels of total CD32 protein.
Anti-CD32 Antibody detects endogenous levels of total CD32 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human CD32.
Immunogen Range: 277-326
Immunogen Range: 277-326
Biochem/physiol Actions
FcγRIIIB/CD32 (Fc fragment of IgG receptor IIb) controls the generation of autoantibodies and their effector roles. During a viral memory response, FcγRIIB blocks the generation of inflammatory type I IFN from plasmacytoid dendritic cells.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Find documentation for the products that you have recently purchased in the Document Library.
Fc?RIIB prevents inflammatory type I IFN production from plasmacytoid dendritic cells during a viral memory response
Flores M, et al.
Journal of Immunology (2015)
Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism Fc?RIIB-T232
Xu L, et al.
The Journal of Experimental Medicine (2016)
Fc?RIIB and autoimmunity
Espeli M, et al.
Immunological Reviews (2016)
Association of a transmembrane polymorphism of Fcgamma receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients
Chen JY, et al.
Arthritis and Rheumatism (2006)
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