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Merck
CN

SAB4500895

Anti-ATF5 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ATF5, Activating transcription factor 5, Cyclic AMP-dependent transcription factor ATF-5, Transcription factor ATFx, cAMP-dependent transcription factor ATF-5

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
Species reactivity:
rat, mouse, human
Citations:
6
Technique(s):
ELISA: 1:1000
western blot: 1:500-1:1000
Uniprot accession no.:
Q9Y2D1

Key Documents

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Product Name

Anti-ATF5 antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 30 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
western blot: 1:500-1:1000

NCBI accession no.

Q9Y2D1

UniProt accession no.

Q9Y2D1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ATF5(22809)

Biochem/physiol Actions

Activating transcription factor 5 (ATF5) participates in metabolite homeostasis, cellular proliferation, differentiation, apoptosis and regulation of the cell cycle. It controls neural progenitor cell and adipose-derived stem cell differentiation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Activating transcription factor 5 (ATF5) belongs to the ATF/cAMP response element-binding protein family. It is an anti-apoptotic protein that has 282 amino acids and is located on human chromosome 19q13. It is expressed in various cancers like prostate, rectal, colon, endometrium, breast, ovary, pancreas, gastric etc.
Anti-ATF5 Antibody detects endogenous levels of total ATF5 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human ATF5.

Immunogen Range: 221-270

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
3111931

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Role of ATF5 in the invasive potential of diverse human cancer cell lines
Nukuda A, et al.
Biochemical and Biophysical Research Communications, 474, 509-514 (2016)
Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells
Ishihara S, et al.
Oncotarget, 6, 4602-4614 (2015)
DNA methylation level of promoter region of activating transcription factor 5 in glioma
Hua XM, et al.
Journal of Zhejiang University. Science. B, 16, 757-762 (2015)
ATF5 (activating transcription factor 5)
Ching A KK and Wong N
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
Kari A Gaither et al.
PloS one, 15(6), e0225044-e0225044 (2020-07-01)
Cellular stress response mechanisms normally function to enhance survival and allow for cells to return to homeostasis following an adverse event. Cancer cells often co-opt these same mechanisms as a means to evade apoptosis and mitigate a state of constant
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