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Merck
CN

SAB4500930

Anti-MAST3 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

KIAA0561, MAST3, Microtubule-associated serine/threonine-protein kinase 3

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
2

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 143 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000, western blot: 1:500-1:1000

NCBI accession no.

O60307

UniProt accession no.

O60307

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MAST3(23031)

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General description

Anti-MAST3 Antibody detects endogenous levels of total MAST3 protein. Microtubule associated serine/threonine kinase 3 (MAST3) belongs to the MAST kinase family. It is composed of 1309 amino acids. The MAST3 gene is 53.9kb long and has 27 exons. It is localized on human chromosome 19p13.11. MAST3 possesses four α-helix bundles having various domains, including a protein kinase domain and a PDZ domain.

Immunogen

The antiserum was produced against synthesized peptide derived from human MAST3.

Immunogen Range: 1031-1080

Biochem/physiol Actions

Microtubule associated serine/threonine kinase 3 (MAST3) modulates the activity of nuclear factor κ-B (NF-κB). It may have a role in inflammatory pathways. Knockdown of MAST3 has been shown to reduce NF-κB activity, which is dependent on toll-like receptor-4.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
3110132

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Genomic alterations identified by array comparative genomic hybridization as prognostic markers in tamoxifen-treated estrogen receptor-positive breast cancer
Wonshik Han
BMC Cancer (2006)
MAST3: a novel IBD risk factor that modulates TLR4 signaling.
Labbe C
Genes and Immunity (2008)

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