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Merck
CN

SAB4501277

Anti-GPR35 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

GPR35, Probable G-protein coupled receptor 35

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
6

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 34 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000

NCBI accession no.

Q9HC97

UniProt accession no.

Q9HC97

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... GPR35(2859)

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General description

Anti-GPR35 Antibody detects endogenous levels of total GPR35 protein.

GPR35 (G protein-coupled receptor 35) is a lysophosphatidic acid receptor. It is highly expressed in the immune and gastrointestinal systems, dorsal root ganglia, cerebellum and brain. It is mapped to human chromosome 2q37.3 .

Immunogen

The antiserum was produced against synthesized peptide derived from human GPR35.

Immunogen Range: 51-100

Biochem/physiol Actions

GPR35 (G protein-coupled receptor 35) is involved in heart failure and pain perception. It also participates in the formation of gastric cancer. It serves as a receptor for the kynurenine pathway intermediate kynurenic acid. It can also acts as an important lysophosphatidic acid receptor.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
61338

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Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35
Wang J, et al.
The Journal of Biological Chemistry, 281(31), 22021-22028 (2006)
Crucial positively charged residues for ligand activation of the GPR35 receptor
Zhao P, et al.
The Journal of Biological Chemistry, 289(6), 3625-3638 (2014)
Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells
Okumura S, et al.
Cancer Science, 95(2), 131-135 (2004)
GPR35 as a Novel Therapeutic Target
Mackenzie AE, et al.
Frontiers in Endocrinology, 2 (2011)
GPR35 is a novel lysophosphatidic acid receptor
Oka S, et al.
Biochemical and Biophysical Research Communications, 395(2), 232-237 (2010)
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