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Merck
CN

SAB4501294

Anti-GLUR1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 101 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P42261

UniProt accession no.

P42261

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GRIA1(2890)

General description

Anti-GLUR1 Antibody detects endogenous levels of total GLUR1 protein.
The gene encoding GLUR1/GRIA1 (glutamate ionotropic receptor AMPA type subunit 1) is localized on human chromosome 5q33.2. It is expressed mainly in the brain. GLUR1 is a glutamate receptor subunit, which forms a glutamate-gated ion channel. It is part of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor family.

Immunogen

The antiserum was produced against synthesized peptide derived from human GluR1.

Immunogen Range: 829-878

Biochem/physiol Actions

GLUR1/GRIA1 (glutamate ionotropic receptor AMPA type subunit 1) plays an important role in long-term potentiation (LTP). It has been associated with migraine.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
217095

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Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission
Kuroyanagi T, et al.
Proceedings of the National Academy of Sciences of the USA, 106(12), 4912-4916 (2009)
Selective disruption of stimulus-reward learning in glutamate receptor gria1 knock-out mice
Mead AN and Stephens DN
The Journal of Neuroscience, 23(3), 1041-1048 (2003)
Common variants in the regulative regions of GRIA1 and GRIA3 receptor genes are associated with migraine susceptibility
Formicola D, et al.
BMC Medical Genetics, 11(1), 103-103 (2010)
Functional organization of the GluR1 glutamate receptor promoter
Borges K and Dingledine R
The Journal of Biological Chemistry, 276(28), 25929-25938 (2001)

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