SAB4501309
Anti-GR antibody produced in rabbit
affinity isolated antibody
Synonym(s):
GCR, GRL, GRL1, NR3C1, glucocorticoid receptor
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC, WB
Citations:
13
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 85 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NR3C1(2908)
General description
Glucocorticoid receptor (GR) gene/NR3C1 (nuclear receptor subfamily 3 group C member 1) is located on human chromosome 5q31. It belongs to the steroid receptor superfamily that consists of ligand-activated nuclear transcription factors.
Immunogen
The antiserum was produced against synthesized peptide derived from human GR.
Immunogen Range: 181-230
Immunogen Range: 181-230
Application
Anti-GR antibody has been used in western blotting.
Biochem/physiol Actions
The glucocorticoid receptor (GR) gene/(NR3C1) is associated with asthma. It is required for glucose homeostasis, hyperinsulinemia and increased fat deposition. It also regulates cell differentiation, nervous and immune system functions.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
低风险生物材料
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Ken Kobayashi et al.
Toxicology in vitro : an international journal published in association with BIBRA, 63, 104741-104741 (2019-11-30)
Nicotine from tobacco smoke is absorbed into the bloodstream and transferred into breast milk in breastfeeding mothers. Smoking causes a decrease in breast milk volume, adverse changes to the milk composition, and a shortened lactation period. Breast milk is produced
Yalan Deng et al.
Nature communications, 12(1), 7041-7041 (2021-12-08)
Despite unprecedented responses of some cancers to immune checkpoint blockade (ICB) therapies, the application of checkpoint inhibitors in pancreatic cancer has been unsuccessful. Glucocorticoids and glucocorticoid receptor (GR) signaling are long thought to suppress immunity by acting on immune cells.
Prolactin and glucocorticoid signaling induces lactation-specific tight junctions concurrent with ?-casein expression in mammary epithelial cells
Kobayashi K, et al.
Biochimica et Biophysica Acta, 1863(8), 2006-2016 (2016)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4501309-100UG | 04061837744501 |