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Merck
CN

SAB4501662

Anti-Keratin 17 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CK-17, Cytokeratin-17, K17, Keratin type I cytoskeletal 17

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 48 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

Q04695

UniProt accession no.

Q04695

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KRT17(3872)

General description

Anti-Keratin 17 antibody detects endogenous levels of total Keratin 17 protein.
Keratin 17/cytokeratin 17 (CK17) is a basal/myoepithelial cell keratin. It is expressed in the respiratory tract, urinary tract and various glands. CK17 is a member of the acidic type I CK family. It is mapped to human chromosome 17q21.

Immunogen

The antiserum was produced against synthesized peptide derived from human Keratin 17.

Immunogen Range: 381-430

Application

Anti-Keratin 17, C-Terminal antibody has been used in immunohistochemical staining.

Biochem/physiol Actions

Keratin 17/cytokeratin 17 (CK17) plays a major role in the development of various human malignancies. It acts as a biomarker in endocervical glandular neoplasia. CK17 is involved in the development of cell and sizing of keratinocytes.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
310242

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Pachyonychia Congenita
Smith FJD, et al.
GeneReviews(?) (2006)
PAR2 regulates regeneration, transdifferentiation, and death
Piran R, et al.
Cell Death & Disease, 7(11), e2452-e2452 (2016)
Keratin 17 Is a Prognostic Biomarker in Endocervical Glandular Neoplasia
Mockler D, et al.
American Journal of Clinical Pathology, 148(3), 264-273 (2017)
Ron Piran et al.
Cell death & disease, 7(11), e2452-e2452 (2016-11-04)
Understanding the mechanisms by which cells sense and respond to injury is central to developing therapies to enhance tissue regeneration. Previously, we showed that pancreatic injury consisting of acinar cell damage+β-cell ablation led to islet cell transdifferentiation. Here, we report
Overexpression of cytokeratin 17 is associated with the development of papillary thyroid carcinoma and the presence of lymph node metastasis
Kim HS, et al.
International Journal of Clinical and Experimental Pathology, 8(5), 5695-5695 (2015)
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