SAB4501719
Anti-LAMA4 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
LAMA4, Laminin subunit α-4
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 202 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LAMA4(3910)
General description
Anti-LAMA4 Antibody detects endogenous levels of total LAMA4 protein.
Laminin-A4 (LAMA4) is a protein that is expressed at high levels in vivo in clusters of hypertrophic chondrocytes. It is located on human chromosome 6q21.
Laminin-A4 (LAMA4) is a protein that is expressed at high levels in vivo in clusters of hypertrophic chondrocytes. It is located on human chromosome 6q21.
Immunogen
The antiserum was produced against synthesized peptide derived from human LAMA4.
Immunogen Range: 481-530
Immunogen Range: 481-530
Application
Anti-LAMA4 antibody has been used in western blotting, immunohistochemistry and immunocytochemistry.
Biochem/physiol Actions
Laminin-A4 (LAMA4) decreases the amount of cellular protrusions in cultured human chondrocytes. It participates in migration, proliferation and survival of several cells. LAMA4 induces invasion, migration and angiogenesis of trophoblast cell.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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N Shan et al.
Placenta, 36(8), 809-820 (2015-06-11)
The laminin α4 subunit (LAMA4) has been shown to promote migration, proliferation, and survival of various cell types. This study investigated LAMA4's role in trophoblast cells during placental development. LAMA4 expression was immunohistochemically assessed in the first trimester and term
Laminin α4 (LAMA4) expression promotes trophoblast cell invasion, migration, and angiogenesis, and is lowered in preeclamptic placentas.
Shan N, et al,
Placenta, 36(8), 809?820-809?820 (2015)
Effect of Laminin?A4 inhibition on cluster formation of human osteoarthritic chondrocytes.
Moazedi?Fuerst FC, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 34(3), 419-426 (2016)
The laminin family.
Aumailley M.
Cell adhesion & migration, 7(1), 48-55 (2013)
Anna Goddi et al.
Endocrinology, 163(11) (2022-09-21)
Laminin-α4 (LAMA4) is an extracellular matrix protein implicated in the regulation of adipocyte differentiation and function. Prior research describes a role for LAMA4 in modulating adipocyte thermogenesis and uncoupling protein-1 (UCP1) expression in white adipose; however, the mechanisms involved are
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