SAB4501820
Anti-MAP4 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
MAP 4, MTAP4, Microtubule-associated protein 4
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 121 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MAP4(4134)
General description
Anti-MAP4 antibody detects endogenous levels of total MAP4 protein.MAP4 (microtubule-associated protein 4) is mapped to human chromosome 3p21.31. The encoded protein is ubiquitously expressed in all cells except for the neurons. MAP4 structure contains a projection domain and a microtubule-binding (MTB) domain at the N- and C-terminal respectively.
Immunogen
The antiserum was produced against synthesized peptide derived from human MAP4.
Immunogen Range: 662-711
Immunogen Range: 662-711
Biochem/physiol Actions
Microtubule-associated protein 4 (MAP4) affects microtubule assembly, stabilization and dynamics through septin interaction. MAP4 promotes apoptosis by p53 regulation. MAP4 mediates the involvement of microtubules in cell division and migration, vesicular transport or generation of primary cilia. It specifically influences mitotic spindle and centrosome position. It is known to stimulate type I IFN (interferon) signaling, which is necessary for innate immune response. MAP4 is associated with the process of invasion and metastasis of esophageal squamous cancer. It might serve as a biomarker for the same.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Chromosomal aberrations and gene expression profiles in non-small cell lung cancer
Dehan E, et al.
Lung Cancer, 56(2), 175-184 (2007)
Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma
Xia X, et al.
Disease Markers, 2018 (2018)
MAP4-regulated dynein-dependent trafficking of BTN3A1 controls the TBK1-IRF3 signaling axis
Seo M, et al.
Proceedings of the National Academy of Sciences of the USA, 113(50), 14390-14395 (2016)
Microtubule associated protein-4 (MAP4) controls nanovesicle dynamics and T cell activation
Bustos-Moran E, et al.
Journal of Cell Science (2017)
Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma
Jiang YY, et al.
Oncogene, 35(37), 4846-4846 (2016)
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