SAB4501849
Anti-MDM2 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Double minute 2 protein, HDM2, Oncoprotein Mdm2, Ubiquitin-protein ligase E3 Mdm2, p53-binding protein Mdm2
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
6
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 55 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MDM2(4193)
General description
Anti-MDM2 antibody detects endogenous levels of total MDM2 protein.
Murine double minute 2 (MDM2) is an oncogenic protein. It is an E3 ubiquitin-protein ligase, that is mapped to human chromosome 12q15.
Immunogen
The antiserum was produced against synthesized peptide derived from human MDM2.
Immunogen Range: 132-181
Immunogen Range: 132-181
Application
Anti-MDM2 antibody has been used in immunohistochemistry.
Biochem/physiol Actions
Murine double minute 2 (MDM2) is a negative regulator of the p53 tumor suppressor. It regulates cell cycle, cellular differentiation, cell fate determination, DNA repair and transcription. Epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells are induced by MDM2.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
低风险生物材料
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MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells
Chen Y, et al.
British Journal of Cancer, 117(8), 1192-1192 (2017)
Angom Ranjana Devi et al.
Indian journal of clinical biochemistry : IJCB, 36(3), 296-303 (2021-07-06)
Nicotine, responsible for the addictive properties of tobacco, is widely used in nicotine replacement therapy for tobacco use cessation. We investigated the time-dependent effect of treatment with nicotine on the tumor suppressor, DNA repair and immune responses. Swiss Albino mice
HIV-1 Tat potently stabilises Mdm2 and enhances viral replication
Raja R, et al.
The Biochemical Journal (2017)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4501849-100UG | 04061837744976 |