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SAB4501849

Anti-MDM2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Double minute 2 protein, HDM2, Oncoprotein Mdm2, Ubiquitin-protein ligase E3 Mdm2, p53-binding protein Mdm2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00282354
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunofluorescence
western blot
Species reactivity:
human, mouse
Citations:
6
Technique(s):
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
Uniprot accession no.:
Q00987

Key Documents

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Product Name

Anti-MDM2 antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 55 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

Q00987

UniProt accession no.

Q00987

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MDM2(4193)

Related Categories

Application

Anti-MDM2 antibody has been used in immunohistochemistry.

Biochem/physiol Actions

Murine double minute 2 (MDM2) is a negative regulator of the p53 tumor suppressor. It regulates cell cycle, cellular differentiation, cell fate determination, DNA repair and transcription. Epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells are induced by MDM2.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Anti-MDM2 antibody detects endogenous levels of total MDM2 protein.
Murine double minute 2 (MDM2) is an oncogenic protein. It is an E3 ubiquitin-protein ligase, that is mapped to human chromosome 12q15.

Immunogen

The antiserum was produced against synthesized peptide derived from human MDM2.

Immunogen Range: 132-181

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
210508

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Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy
Zhou G, et al.
Investigative Ophthalmology & Visual Science, 58(12), 5361-5367 (2017)
Angom Ranjana Devi et al.
Indian journal of clinical biochemistry : IJCB, 36(3), 296-303 (2021-07-06)
Nicotine, responsible for the addictive properties of tobacco, is widely used in nicotine replacement therapy for tobacco use cessation. We investigated the time-dependent effect of treatment with nicotine on the tumor suppressor, DNA repair and immune responses. Swiss Albino mice
HIV-1 Tat potently stabilises Mdm2 and enhances viral replication
Raja R, et al.
The Biochemical Journal (2017)
MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells
Chen Y, et al.
British Journal of Cancer, 117(8), 1192-1192 (2017)
HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
Italiano A, et al.
International Journal of Cancer. Journal International Du Cancer, 122(10), 2233-2241 (2008)
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