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Merck
CN

SAB4501864

Sigma-Aldrich

Anti-MAP3K4 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

KIAA0213, M3K4, MAP three kinase 1, MAP3K4, MAPK/ERK kinase kinase 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 181 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100

NCBI accession no.

Q9Y6R4

UniProt accession no.

Q9Y6R4

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAP3K4(4216)

General description

Anti-MAP3K4 Antibody detects endogenous levels of total MAP3K4 protein.
MAP3K4 (mitogen-activated protein kinase kinase kinase 4) gene encodes a component of protein kinase signal transduction cascade. It is also termed as MTK1 (MAP3 kinase 1). MAP3K4 contains a protein kinase catalytic domain at the C terminus and a regulatory/autoinhibitory domain at the N-terminus. It is located on human chromosome 6q26.

Immunogen

The antiserum was produced against synthesized peptide derived from human MAP3K4.

Immunogen Range: 1281-1330

Biochem/physiol Actions

MAP3K4 (mitogen-activated protein kinase kinase kinase 4) phosphorylates and activates a specific MAPK kinase (MAPKK) in the cascade through phosphorylation of conserved threonine and/or serine residues. GADD45 (growth arrest and DNA-damage-inducible proteins) proteins interact with and free the autoinhibitory domain from the kinase domain, thus activating MAP3K4. It mediates the activation of p38 MAPK pathway and the JNK (c-Jun N-terminal kinase) pathway induced by environmental stresses.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
3111995

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Comparison between osteoblasts derived from human dental pulp stem cells and osteosarcoma cell lines
Palmieri A, et al.
Cell Biology International, 32(7), 733-738 (2008)
M Takekawa et al.
The EMBO journal, 16(16), 4973-4982 (1997-08-15)
A human homolog of the yeast Ssk2 and Ssk22 mitogen-activated protein kinase kinase kinases (MAPKKK) was cloned by functional complementation of the osmosensitivity of the yeast ssk2delta ssk22delta sho1delta triple mutant. This kinase, termed MTK1 (MAP Three Kinase 1), is
Hiroaki Mita et al.
Molecular and cellular biology, 22(13), 4544-4555 (2002-06-08)
A variety of cellular stresses activate the stress-responsive mitogen-activated protein (MAP) kinases p38 and JNK. In this study, we studied the activation mechanism of a human MAP kinase kinase kinase, MTK1 (also known as MEKK4), which mediates activation of both

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