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Merck
CN

SAB4501900

Anti-MMP-13 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Collagenase 3, MMP-13, MMP13, Matrix metalloproteinase-13

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About This Item

MDL number:
MFCD03455405
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 53 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P45452

UniProt accession no.

P45452

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MMP13(4322)

General description

Anti-MMP-13 Antibody detects endogenous levels of total MMP-13 protein.
Matrix metalloproteinases (MMPs) are a class of extra-cellular and membrane-bound proteases. MMP13 (matrix metallopeptidase 13) is mapped to human chromosome 11q14.3–23.2.

Immunogen

The antiserum was produced against synthesized peptide derived from human MMP-13.

Immunogen Range: 10-59

Biochem/physiol Actions

MMP13 (matrix metallopeptidase 13) participates in tissue remodeling, inflammation, cytokine secretion and activation. It also plays an important role in acute lung injury, viral infections and chronic obstructive pulmonary disease. Mutation in MMP13 results in spondyloepimetaphyseal dysplasia, missouri type (SEMDMO).

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
310265

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MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO).
Kennedy AM, et al.
The Journal of Clinical Investigation, 115(10), 2832-2842 (2005)
Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism
Mashimo Y, et al.
Inflammation, 39(3), 949-962 (2016)
Tiago Nicoliche et al.
PloS one, 15(3), e0230228-e0230228 (2020-03-13)
This study was designed to evaluate the anti-inflammatory effects of a curcumin treatment on the knee of rats with induced osteoarthritis. Fifteen adult rats were used and divided in three groups: the osteoarthritis group (OAG), control group (CG-without induction of

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