SAB4501900
Anti-MMP-13 antibody produced in rabbit
affinity isolated antibody
别名:
Collagenase 3, MMP-13, MMP13, Matrix metalloproteinase-13
产品名称
Anti-MMP-13 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 53 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MMP13(4322)
Biochem/physiol Actions
MMP13 (matrix metallopeptidase 13) participates in tissue remodeling, inflammation, cytokine secretion and activation. It also plays an important role in acute lung injury, viral infections and chronic obstructive pulmonary disease. Mutation in MMP13 results in spondyloepimetaphyseal dysplasia, missouri type (SEMDMO).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-MMP-13 Antibody detects endogenous levels of total MMP-13 protein.
Matrix metalloproteinases (MMPs) are a class of extra-cellular and membrane-bound proteases. MMP13 (matrix metallopeptidase 13) is mapped to human chromosome 11q14.3–23.2.
Immunogen
The antiserum was produced against synthesized peptide derived from human MMP-13.
Immunogen Range: 10-59
Immunogen Range: 10-59
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO).
Kennedy AM, et al.
The Journal of Clinical Investigation, 115(10), 2832-2842 (2005)
Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism
Mashimo Y, et al.
Inflammation, 39(3), 949-962 (2016)
Tiago Nicoliche et al.
PloS one, 15(3), e0230228-e0230228 (2020-03-13)
This study was designed to evaluate the anti-inflammatory effects of a curcumin treatment on the knee of rats with induced osteoarthritis. Fifteen adult rats were used and divided in three groups: the osteoarthritis group (OAG), control group (CG-without induction of
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