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Merck
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SAB4501903

Anti-MMP-15 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

MATRIX METALLOPROTEINASE 15, MEMBRANE-TYPE, MEMBRANE-TYPE MATRIX METALLOPROTEINASE 2, MT2-MMP, matrix metalloproteinase 15 (membrane-inserted)

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
5

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 75 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000, western blot: 1:500-1:1000

NCBI accession no.

P51511

UniProt accession no.

P51511

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MMP15(4324)

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General description

Anti-MMP-15 Antibody detects endogenous levels of total MMP-15 protein.
Matrix metallopeptidase 15 (MMP-15) is encoded by the gene mapped to human chromosome l Iq22.2-22.3. The encoded protein belongs to the membrane-type matrix metalloproteinases (MT-MMPs).

Immunogen

The antiserum was produced against synthesized peptide derived from human MMP-15.

Immunogen Range: 611-660

Biochem/physiol Actions

Frovatriptan is a serotonin 5HT-1B/1D-receptor agonist.
Matrix metallopeptidase 15 (MMP-15) is implicated in the activation of pro-MMP-2 and pro-MMP-13. It is also facilitates tumor necrosis factor a processing. MMP-15 might promote various types of cancer progression, including non-small cell lung cancer (NSCLC). In addition, it also promotes gastric cancer (GC) invasion and metastasis. Thus, this protein can be used as a potent prognostic marker for GC patients.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
310267

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Candidate genes involved in vascular matrix remodelling in atherogenesis
Henney AM.
Experimental Physiology, 84(4), 785-789 (1999)
Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis
Konttinen YT, et al.
Annals of the Rheumatic Diseases, 58(11), 691-697 (1999)
The role of MT2-MMP in cancer progression
Ito E, et al.
Biochemical and Biophysical Research Communications, 393(2), 222-227 (2010)
MT2-MMP expression associates with tumor progression and angiogenesis in human lung cancer
Chen L, et al.
International Journal of Clinical and Experimental Pathology, 7(6), 3469-3469 (2014)
Increased MT2-MMP expression in gastric cancer patients is associated with poor prognosis
Xu X, et al.
International Journal of Clinical and Experimental Pathology, 8(2), 1985-1985 (2015)

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