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SAB4502354

Sigma-Aldrich

Anti-PKC α antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
KPCA, PKC III, PKC-α, PKC-A, kinase PKC-α
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 76 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P17252

UniProt accession no.

P17252

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PRKCA(5578)

General description

Anti-PKC α Antibody detects endogenous levels of total PKC α protein.
PKC α (protein kinase C α) gene is mapped to 17q24.2. PKC α is expressed in heart, liver, brain and epithelium.

Immunogen

The antiserum was produced against synthesized peptide derived from human PKC alpha.

Immunogen Range: 606-655

Biochem/physiol Actions

PKC (protein kinase C) is known to mediate different cellular processes, such as transcription regulation, cell signaling, cell proliferation, immune responses and apoptosis. While PKC is also associated with the learning ability. Abnormal cell signaling induced by PKC is often observed in cancer. PKC α (protein kinase C α) being one of the isozymes of the PKC family, it catalyzes the phosphorylation of substrates with many peptides.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus
Panayiotis K. Yiallouros
Italian Journal of Pediatrics, 42: 67, 1-9 (2016)
Distinct structural mechanisms determine substrate affinity and kinase activity of protein kinase C?.
Lee S
The Journal of Biological Chemistry, 292(39), 16300-16309 (2017)
Polyphenol compounds and PKC signaling.
Das J
Biochimica et Biophysica Acta, 1860(10), 2107-2121 (2016)
Yu Cai et al.
Journal of cellular and molecular medicine, 26(21), 5391-5402 (2022-09-30)
The dysregulation of lipid metabolic pathways (cholesterol uptake and efflux) in macrophages results in the formation of lipid-dense macrophages, named foam cells, that participate in plaque formation. NPY binding to NPY receptors in macrophages can modulate cell functions and affect
Anita Hendrickson et al.
The Journal of comparative neurology, 527(1), 38-51 (2017-01-12)
During retinal development, ribbon synapse assembly in the photoreceptors is a crucial step involving numerous molecules. While the developmental sequence of plexiform layers in human retina has been characterized, the molecular steps of synaptogenesis remain largely unknown. In the present
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