SAB4502469
Anti-GPR126 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
GPR126, Probable G-protein coupled receptor 126
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Anti-GPR126 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 136 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
immunofluorescence: 1:100-1:500
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GPR126(57211)
Biochem/physiol Actions
GPR126 (adhesion G protein-coupled receptor G6) controls the homeostasis of periodontal ligament tissue. GPR126 is responsible for axon myelination of peripheral neurons in human, mice and fish. This gene mediates endothelial cell proliferation and migration, and tube formation, thereby contributing to angiogenesis, which is necessary for overall growth, wound healing and tumor progression.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
G protein-coupled receptor 126 (GPR126) belongs to the adhesion-G protein-coupled receptor (GPCR) family. It is an endothelial cell-enriched gene. The gene is located on human chromosome 6q24.2.
The GPR126 (adhesion G protein-coupled receptor G6) gene codes for a protein that contains an extracellular domain, a seven transmembrane domain at the N-terminal and an intracellular domain in its C-terminal.
Immunogen
The antiserum was produced against synthesized peptide derived from human GPR126.
Immunogen Range: 1091-1140
Immunogen Range: 1091-1140
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Multiethnic GWAS reveals polygenic architecture of earlobe attachment
Shaffer JR, et al.
American Journal of Human Genetics, 101(6), 913-924 (2017)
A Genetic Variant in GPR126 Causing a Decreased Inclusion of Exon 6 Is Associated with Cartilage Development in Adolescent Idiopathic Scoliosis Population
Xu E, et al.
BioMed Research International, 2019 (2019)
Gianina Ravenscroft et al.
American journal of human genetics, 96(6), 955-961 (2015-05-26)
Arthrogryposis multiplex congenita is defined by the presence of contractures across two or more major joints and results from reduced or absent fetal movement. Here, we present three consanguineous families affected by lethal arthrogryposis multiplex congenita. By whole-exome or targeted
Identification of Novel Smoothened Ligands Using Structure-Based Docking.
Lacroix C
PLoS ONE, 11(8), 1-20 (2016)
Hengxiang Cui et al.
The Journal of biological chemistry, 289(50), 34871-34885 (2014-09-14)
Angiogenesis, the formation of new blood vessels from pre-existing ones, is essential for development, wound healing, and tumor progression. The VEGF pathway plays irreplaceable roles during angiogenesis, but how other signals cross-talk with and modulate VEGF cascades is not clearly
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