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Merck
CN

SAB4502626

Anti-DNA Polymerase ζ, N-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(s):

DNA polymerase ζ catalytic subunit, DPOLZ, DPOZ, POLZ, REV3L

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunohistochemistry
Species reactivity:
mouse, human
Citations:
4
Technique(s):
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
Uniprot accession no.:
O60673

Key Documents

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Product Name

Anti-DNA Polymerase ζ, N-Terminal antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 352 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100

NCBI accession no.

O60673

UniProt accession no.

O60673

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... REV3L(5980)

Related Categories

Biochem/physiol Actions

REV3L (reversionless 3-like) is predominantly involved in DNA damage response, induced by ultraviolet radiation and chemical damaging agents such as cisplatin. The encoded protein DNA Polymerase ζ catalyzes the translesion synthesis (TLS) with less stringent and lower processivity. Loss of gene function is embryonically lethal. Upregulation of REV3L results in spontaneous mutations.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Anti-DNA Polymerase ζ antibody detects endogenous levels of total DNA polymerase ζ protein.
The REV3L (reversionless 3-like) gene is mapped to human chromosome 6q21. It codes for a ~350 kDa protein DNA polymerase ζ which localizes to mitochondria.

Immunogen

The antiserum was produced against synthesized peptide derived from human DNA Polymerase zeta.

Immunogen Range: 231-280

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
3110144

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REV3L, the catalytic subunit of DNA polymerase ?, is involved in the progression and chemoresistance of esophageal squamous cell carcinoma.
Zhu X
Oncology Reports, 35(3), 1664-1670 (2016)
Loss of DNA polymerase zeta causes chromosomal instability in mammalian cells.
Wittschieben JP
Cancer Research, 66(1), 134-142 (2006)
Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells.
Jiang HG
Journal of Cellular Physiology, 232(12), 3433-3443 (2017)
Tris-(2,3-Dibromopropyl) Isocyanurate, a New Emerging Pollutant, Impairs Cognition and Provokes Depression-Like Behaviors in Adult Rats.
Ye L
PLoS ONE, 10(10), 1-16 (2015)

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